Results 31 to 40 of about 541,036 (231)

Re-establishment and Regarding Trust and Transparency, Blockchain’s Contribution to the Solution of a Thousand-Year Problem

open access: yesDüzce Üniversitesi Bilim ve Teknoloji Dergisi, 2021
Trust is the most important key element in the history of humanity and its success. We see and witness an emerging and exciting technology called Blockchain, eliminating losses caused by anti-trust and relieves pain in our social-build environment ...
Nataliia Krasnokutska, Koray Adıgüzel
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The global value chain dimension of foreign direct investment flows in the agro-industrial sector of South Africa, 2003–2014

open access: yesActa Commercii, 2018
Orientation: African countries offer many investment opportunities and also urgently need global investment finance. Along the value chains of the agro-industrial sector there are many global challenges for African countries to attract foreign direct ...
Henri Bezuidenhout   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Iron ore development management in the Russian Federation

open access: yesУправление
The Russian mineral resource complex is the basis for economy real sector development. The reserves of oil, gas, ferrous and non-ferrous metals, timber, and other raw materials are the strategic basis for the state economic development stability.
A. M. Belyaev   +2 more
doaj   +1 more source

A Systematic Analysis of how Practitioners Articulate Business Models across Disruptive Industries

open access: yesTechnology Innovation Management Review, 2020
Ongoing debates surround the role of business models in understanding the dynamics related to disruptive innovation. Too little is still known about how practitioners highlight different characteristics of business models across industries confronted ...
Alina Marie Herting   +1 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

التحليل الجغرافي للصناعات الصغيرة في مركز الزقازيق [PDF]

open access: yesMaǧallaẗ Kulliyyaẗ Al-ādāb Ǧāmiʿaẗ Būrsaʿīd
قيام أي نشاط صناعي لابد له من مقومات طبيعية و بشرية, وجاء هذا البحث ليسلط الضوء على الصناعات الصغيرة في مركز الزقازيق، والتعرف علي توزيعها الجغرافي لمواقع الصناعات الصغيرة في مركز الزقازيق، كما ركز الباحث على بيان دور العوامل المؤثرة في الصناعات والتي ...
رأفت عثمان سلامة تمراز
doaj   +1 more source

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