Results 41 to 50 of about 1,083,210 (301)
In the context of accelerated digitalization, enterprises are increasingly adopting information-driven solutions to support managerial decision-making, with Enterprise Resource Planning (ERP) systems playing a crucial role in organizational development ...
Aleksandra Radić +4 more
doaj +1 more source
التحليل الجغرافي للصناعات الصغيرة في مركز الزقازيق [PDF]
قيام أي نشاط صناعي لابد له من مقومات طبيعية و بشرية, وجاء هذا البحث ليسلط الضوء على الصناعات الصغيرة في مركز الزقازيق، والتعرف علي توزيعها الجغرافي لمواقع الصناعات الصغيرة في مركز الزقازيق، كما ركز الباحث على بيان دور العوامل المؤثرة في الصناعات والتي ...
رأفت عثمان سلامة تمراز
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
METODE PENDUGAAN KEMAMPUAN SUPPLY PRODUK KAYU DARI BERBAGAI INDUSTRI DI PROPINSI RIAU
The aim of this investigation is to create a prediction model on the potentiality of supplying merchant wood products. The investigation was carried out in the province of Riau Four Sawmills and two plywood industries were selected for this study.
Han Roliadi, Buharman Buharman
doaj +1 more source
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Creative Industries Innovation Centre Closure Q&A.pdf
Information about the of the Creative Industries Innovation Centre in Q&A form, with information about creative business support services through the Entrepreneurs' Infrastructure Programme, final Biztro sessions, and a link to the Creative Industries ...
Creative Industries Innovation Centre
core
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source

