Results 61 to 70 of about 2,972,702 (296)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Identification of cereal seedlings [PDF]
In order to identify different cereal species, close observation of the seedlings at the junction of the leaf-sheath and leaf-blade is required.
Department of Environment and Primary Industries
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
STRENGTHENING OF A FIRM COMPETITIVENESS THROUGH INDUSTRIAL POLICY: A LITERATURE REVIEW
Экономика: стратегия и практика, 2019 The aim of this paper is evaluation different studies related to the industrial policy and its capabilities to increase competitive power of domestic companies, highlighting factors that affect results of such policy and performance of firms.
A. M. Seitkaziyeva +2 more
doaj
Rethinking the Value of Education amid the Economic Crisis: The Experiences of University Graduates
Education SciencesEven though many nations invest heavily in education to boost economic growth and development, evidence continues to show that university graduates struggle to find employment and eke out a living, obscuring our understanding of the true value of ...
Pfuurai Chimbunde, Byron Brown
doaj +1 more source
Effect of frost on cereal grain crops [PDF]
Loss of wheat production due to frost damage is not common in Victoria. However, while the total loss is rarely great, individual growers can suffer heavy losses in some years.
Department of Environment and Primary Industries
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Guideline for Cross-Sector Coupling of Carbon Capture Technologies
GasesMany governments around the world have taken action to utilise carbon capture (CC) technologies to reduce CO2 emissions. This technology is particularly important to reduce unavoidable emissions from industries like cement plants, oil refineries, etc ...
Hossein Asgharian +5 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source