Results 61 to 70 of about 541,036 (231)

A modeling of internal effective factors over small and medium enterprises performance [PDF]

Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2015
: In response to bankruptcy of several small and medium enterprises(SMEs) in Mazandaran province, this research is conducted to identify the internal key factors that affect the performance of this enterprises.
Vali MOhamad Darini, Ali Akbar Aghajani Afroozi, Mohamad Taban, Morteza Mohamadi saleh   +3 more
doaj  

The K to 12 Senior High School Technica-Vocational Livelihood Track is Not at All Ready for Implementation

JPAIR Institutional Research Journal, 2015
The K to 12 program in the Philippines was enacted into law on May 15, 2013, through Republic Act 10533, otherwise known as the Enhanced Basic Education Act of 2013.
Florencio R. Caballero, Ruth G. Cabahug
doaj   +1 more source

Mozambique’s industrialization [PDF]

, 2014
After the Second World War, Mozambique went through a series of transformations, from an incipient industrializing colonial society to an independent country with a central planned economy, plus a regional and internal war, and finally from 1994 onwards, a multi-party democracy with a mix of market economy and a still strong public hand.
Sousa Cruz, António, Guambe, Dina, Marrengula, Constantino Pedro, Ubisse, Amosse Francisco   +3 more
openaire   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Hacia una historia social de la psicología peruana

Revista de Psicología, 2018
Este trabajo ofrece una visión acerca de la psicología peruana, pero desde el enfoque de la historia social. Varios hechos económicos, sociológicos, políticos y de las actitudes son mostrados. Todos ellos estuvieron vinculados con la joven psicología en
Arturo Orbegoso Galarza
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Analysis of Artificial Intelligence Exposure Across Industries in South Korea and the United States

East Asian Economic Review
This study examines the impact of AI exposure on industries in South Korea and the United States from 2019 to 2022, using the AI Industry Exposure (AIIE) index developed by Felten et al. (2021).
Yaein Baek, Jiyun Lee
doaj   +1 more source