Results 51 to 60 of about 10,873,447 (395)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Human-Centric Digital Twins in Industry: A Comprehensive Review of Enabling Technologies and Implementation Strategies [PDF]
, 2023 Usman Asad +3 more
openalex +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
, 2003 As the speed of Internet access improves, the film industry will need to explore its options for eliminating the downloading of digital movie files. After examining the successes and failures of the music industry in its battle with peer-to-peer networks,
Bedel, A. J.
core +2 more sources
Exploring the Link between Sustainable Practices and Corporate Performance Across Industries
Business Systems ResearchThe adoption of the Sustainable Development Goals (SDGs) has set a global standard for promoting sustainable practices. However, manufacturing companies need help in adopting these practices due to differences between industries, the need for research ...
Osorio Iris Maria Velez
doaj +1 more source
TeMA: Journal of Land Use, Mobility and EnvironmentThe asymmetrical process of industrial development tends to increase regional disparities and result in different patterns of territorial exposure: the amount of support given to activities placed within industrial agglomerates.
Diego Altafini, Valerio Cutini
doaj +1 more source
Silk Sericin Protein Materials: Characteristics and Applications in Food-Sector Industries [PDF]
, 2023 Su-Jin Seo +3 more
openalex +1 more source
Optimal Scheduling of Trains on a Single Line Track [PDF]
, 1996 This paper describes the development and use of a model designed to optimise train schedules on single line rail corridors. The model has been developed with two major applications in mind, namely: as a decision support tool for train dispatchers to ...
A. Higgins +18 more
core +2 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source