Results 51 to 60 of about 10,424,348 (384)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

The Industry Advisory Board Event - A Decade of Best Practices [PDF]

, 2019
As the leading global advocate of quality construction education, the mission of the American Council for Construction Education1 (ACCE) is to promote, support, and accredit quality construction education programs.
Labas, Susan, McIntyre, Charles
core  

The history of plastics: from the Capitol to the Tarpeian Rock

Field Actions Science Reports, 2019
Few industries like plastic have experienced similar growth in the space of 60 years, both in terms of production tonnage and use in virtually every moment of our daily lives. However, plastic is now victim of its own success.
Philippe Chalmin
doaj  

Petru Sebeşanu Aurelian – The First Economist of the Romanian Academy [PDF]

Ovidius University Annals: Economic Sciences Series, 2020
Petru Sebeşanu Aurelian was born in Slatina on December 13, 1833 and he died in Bucharest on January 24, 1909. He is one of the most prominent people in the 19th century Romania.
Sorinel Cosma
doaj  

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Assessment of highly distributed power systems using an integrated simulation approach [PDF]

, 2008
In a highly distributed power system (HDPS), micro renewable and low carbon technologies would make a significant contribution to the electricity supply. Further, controllable devices such as micro combined heat and power (CHP) could be used to assist in
Anderson K., Clarke J. A., DTI, Department for Trade and Industry, DTI, Department for Trade and Industry, DTI, Department for Trade and Industry, Elders I., G M Burt, I M Elders, Jardine C., Kelly N. J., N J Kelly, R M Tumilty, Royal Commission on Environmental Pollution, S J Galloway   +13 more
core   +1 more source

Recent Developments and Aspects of Industrial Fluoroalkylation

CHIMIA, 2021
Fluoroalkylations have received increasing attention in the academic and industrial environment due to the particular properties of the active ingredients that are strongly influenced by fluoroalkyl substituents.
Matthias Keller, Florian Fischer, Andreas Locher, Helfried Neumann, Christoph Taeschler, Fei Ye, Shaoke Zhang   +6 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Interrogating the Migration Industry [PDF]

, 2016
Review of Ruben Andersson,Illegality, Inc. (Oakland, CA: University of California Press, 2014)and Amy Nethery and Stephanie J. Silverman(eds.), Immigration Detention: The Migration of a Policy and its Human Impact.(London and New York: Routledge ...
Sager, Alex
core   +2 more sources