Results 81 to 90 of about 8,666,022 (338)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Placement and Implementation of Grid-Forming and Grid-Following Virtual Inertia and Fast Frequency Response [PDF]

IEEE Transactions on Power Systems, 2018
The electric power system is witnessing a shift in the technology of generation. Conventional thermal generation based on synchronous machines is gradually being replaced by power electronics interfaced renewable generation.
B. Poolla, Dominic Gross, F. Dörfler
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Coordinated control strategy for improving inertial response and primary frequency modulation in wind power full DC system

电力工程技术
A coordinated control strategy for a variable-coefficient wind power full DC system to address problems such as reduced system inertia and insufficient frequency regulation abilities in the AC grid caused by the integration of wind power full DC systems ...
RU Dong, LIN Hong
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Dust trapping in inviscid vortex pairs

, 2010
The motion of tiny heavy particles transported in a co-rotating vortex pair, with or without particle inertia and sedimentation, is investigated. The dynamics of non-inertial sedimenting particles is shown to be chaotic, under the combined effect of ...
Angilella, Chein, Davila, Druzhinin, Ferrante, Fung, Guckenheimer, Haller, Jean-Régis Angilella, Kiger, Maclaughlin, Marcu, Maxey, Maxey, Michael, Raju, Rubin, Stommel, Tsega, Vilela, Wang   +20 more
core   +1 more source

Inertia emulation control of VSC-HVDC transmission system [PDF]

, 2011
The increasing penetration of power electronics interfaced renewable generation (e.g. offshore wind) has been leading to a reduction in conventional synchronous-machine based generation.
Adam, Grain Philip, Booth, Campbell, Roscoe, Andrew, Zhu, Jiebei   +3 more
core   +1 more source

Velocity gradients statistics along particle trajectories in turbulent flows: the refined similarity hypothesis in the Lagrangian frame [PDF]

, 2009
We present an investigation of the statistics of velocity gradient related quantities, in particluar energy dissipation rate and enstrophy, along the trajectories of fluid tracers and of heavy/light particles advected by a homogeneous and isotropic ...
Detlef Lohse, E. Calzavarini, Enrico Calzavarini, Federico Toschi, Luca Biferale, R. Gatignol, Roberto Benzi, S. B. Pope, U. Frisch   +8 more
core   +7 more sources

Frequency Inertia Response Control of SCESS-DFIG under Fluctuating Wind Speeds Based on Extended State Observers

, 2018
Insufficient frequency regulation capability and system inertia reduction are common problems encountered in a power grid with high wind power penetration, mainly due to the reason that the rotor energy in doubly fed induction generators (DFIGs) is ...
Dongyang Sun, Lizhi Sun, Fengjiang Wu, Guangxin Zu   +3 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source