Results 21 to 30 of about 9,861 (247)

A model-based cost-effectiveness estimates of hormonal therapy in Indian children with infantile epileptic spasms syndrome. [PDF]

Epilepsia Open
Due to the conflicting evidence and expected regional therapeutic variations for cost‐effectiveness in children with infantile epileptic spasms syndrome (IESS), this study assessed treatment effectiveness, safety, Health‐Related Quality of Life (HRQoL ...
Devi N, Madaan P, Bharti SK, Sahu JK, Bansal D.   +4 more
europepmc   +2 more sources

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review. [PDF]

Dev Med Child Neurol
To review the aetiopathogenesis of infantile epileptic spasms syndrome (IESS) and mechanisms of action of adrenocorticotrophin hormone (ACTH)/corticosteroids established in humans.
Innes EA, Han VX, Patel S, Farrar MA, Gill D, Mohammad SS, Dale RC.   +6 more
europepmc   +2 more sources

Distinct T Cell Dysregulation Reflects Disease Severity and Progression in Infantile Epileptic Spasms Syndrome and Lennox-Gastaut Syndrome. [PDF]

Immune Netw
Developmental and epileptic encephalopathies (DEEs), including Infantile Epileptic Spasms Syndrome (IESS) and Lennox-Gastaut Syndrome (LGS), are severe pediatric conditions characterized by profound developmental delays and treatment-resistant epilepsy ...
Chang L, Jeong YJ, Chang H, Sang HD, Kwon KN, Lee SB, Kim SY, Kang YM, Ha S, Kim SH, Cheon KA, Kwon HK.   +11 more
europepmc   +2 more sources

Efficacy of vigabatrin in the treatment of infantile epileptic spasms syndrome: A systematic review and meta-analysis. [PDF]

Epilepsia Open, 2023
This systematic review and meta‐analysis aimed to evaluate the efficacy of vigabatrin (VGB) in treating infantile epileptic spasms syndrome (IESS). Databases of PubMed, Embase, Web of Science, MEDLINE, and Cochrane Library were systematically searched ...
Xu Z, Gong P, Jiao X, Niu Y, Wu Y, Zhang Y, Chang X, Yang Z.   +7 more
europepmc   +2 more sources

IESS-FusionNet: Physiologically Inspired EEG-EMG Fusion with Linear Recurrent Attention for Infantile Epileptic Spasms Syndrome Detection [PDF]

Bioengineering
Infantile Epileptic Spasms Syndrome (IESS) is a devastating epileptic encephalopathy of infancy that carries a high risk of lifelong neurodevelopmental disability.
Junyuan Feng, Zhenzhen Liu, Linlin Shen, Xiaoling Luo, Yan Chen, Lin Li, Tian Zhang   +6 more
doaj   +2 more sources

The genetic landscape and classification of infantile epileptic spasms syndrome requiring surgery due to suspected focal brain malformations. [PDF]

Brain Commun
Infantile epileptic spasms syndrome is a severe epilepsy of infancy that is often associated with focal malformations of cortical development. This study aimed to elucidate the genetic landscape and histopathologic aetiologies of infantile epileptic ...
Coleman M, Wang M, Snell P, Lee WS, D'Arcy C, Mignone C, Pope K, Gillies G, Maixner W, Wray A, Harvey AS, Simons C, Leventer RJ, Stephenson SEM, Lockhart PJ, Howell KB.   +15 more
europepmc   +2 more sources

Infantile epileptic spasms syndrome as a new phenotype in TOP2B deficiency caused by a <i>de novo</i> variant: a case report and literature review. [PDF]

Front Pediatr
Background: Type II DNA topoisomerases (EC5.99.1.3) are enzymes that catalyze topological changes during DNA replication and gene transcription in an ATP-dependent manner. Vertebrates have two isoforms: topoisomerase IIα and β. Type II topoisomerase β is
Zhu GQ, Yao Y, Yang LY, Hua Y, Li GM.
europepmc   +2 more sources

Association Between Scalp High-Frequency Oscillations and Burden of Amplitudes and Epileptiform Discharges (BASED) Scores in Infantile Epileptic Spasms Syndrome. [PDF]

Biomolecules
Tools for measuring the likelihood of relapse in infantile epileptic spasms syndrome (IESS) treatment could aid clinicians in making critical management decisions.
Maeda K, Tsuboi H, Hosoda N, Fukumoto J, Fujita S, Yamaguchi S, Ichino N, Osakabe K, Sugimoto K, Furukawa G, Ishihara N.   +10 more
europepmc   +2 more sources

Association of serum insulin-like growth factor-1 and adrenocorticotropic hormone therapeutic response in patients with infantile epileptic spasms syndrome. [PDF]

Front Pharmacol
Background Infantile epileptic spasm syndrome (IESS), a rare age-specific epileptic encephalopathy, exhibits limited therapeutic efficacy, with approximately 50% of patients showing resistance to adrenocorticotropic hormone (ACTH) monotherapy. Herein, we
Lin KN, Han F, Wang YY, Zhao W, Wang JW, Li H, Zhou YQ.   +6 more
europepmc   +2 more sources

A Multicenter Training and Interrater Reliability Study of the BASED Score for Infantile Epileptic Spasms Syndrome. [PDF]

J Clin Neurophysiol
Purpose: The best possible outcomes in infantile epileptic spasms syndrome require electroclinical remission; however, determining electrographic remission is not straightforward.
Mytinger JR, Albert DVF, Aylward SC, Beatty CW, Bhalla S, Bhatia S, Brock GN, Ciliberto MA, Choudhari PR, Clark DJ, Cohen JM, Czech TM, Fredwall MM, Gonzalez-Giraldo E, Harini C, Hunter SE, Sandoval Karamian AG, Katyayan A, Kistler I, Kulkarni N, Liu VB, McCabe C, Murray T, Neville K, Patel SH, Pavuluri S, Phillips DJ, Samanta D, Sirsi D, Spelbrink EM, Stafstrom CE, Steenari M, Takacs DS, Terrill T, Tran L, Vidaurre J, Shrey DW.   +36 more
europepmc   +2 more sources