Results 31 to 40 of about 9,861 (247)

Clinical profile and treatment of infantile spasms using vigabatrin and ACTH - a developing country perspective [PDF]

BMC Pediatrics, 2010
Background Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment.
Ishaque Sidra, Gulab Shamshad, Ibrahim Shahnaz, Saleem Taimur   +3 more
doaj   +5 more sources

EEG functional connectivity as a marker of evolution from infantile epileptic spasms syndrome to Lennox-Gastaut syndrome.

Epilepsia, EarlyView.
OBJECTIVE Timely diagnosis and effective treatment of Lennox-Gastaut syndrome (LGS) improve prognosis and lower health care costs, but the transition from infantile epileptic spasms syndrome (IESS) to LGS is highly variable and insidious.
Blanca Romero Milà, Virginia B. Liu, Rachel J. Smith, Derek K Hu, Natalie A. Benneian, Shaun A Hussain, Maija Steenari, Donald Phillips, David J Adams, Clare Skora, Beth A. Lopour, Daniel W. Shrey   +11 more
semanticscholar   +2 more sources

Epileptic spasms relapse is associated with response latency but not conventional attributes of post‐treatment EEG [PDF]

Epilepsia Open
Objective Relapse of epileptic spasms after initial treatment of infantile epileptic spasms syndrome (IESS) is common. However, past studies of small cohorts have inconsistently linked relapse risk to etiology, treatment modality, and EEG features upon ...
Emmi Deckard, Rujuta Sathe, David Tabibzadeh, Aria Terango, Aran Groves, Rajsekar R. Rajaraman, Hiroki Nariai, Shaun A. Hussain   +7 more
doaj   +2 more sources

Cohort study of infantile epileptic spasms syndrome: etiological analysis and treatment of corticosteroids

Seizure: European Journal of Epilepsy, 2022
BACKGROUND Infantile epileptic spasms syndrome (IESS) is the most common type of severe epilepsy in infants. However, etiological frequency and optimized therapy, particularly corticosteroid regimen and dose, remain unknown.
Yu Jiang, Nan Zou, Yuan Luo, M. Cheng, S. Liao, Si-qi Hong, Xiaohua Liang, Min Zhong, Tingsong Li, Li Jiang   +9 more
semanticscholar   +3 more sources

Brain tumours as an unrecognized etiology of infantile epileptic spasms syndrome (IESS): The role of resective epilepsy surgery. [PDF]

Epilepsy Behav Rep
Pentz R, Jones K, Mesterman R, RamachandranNair R, Otsubo H, Ochi A, Yau I, Donner EJ, Ibrahim GM, Jain P, Whitney R.   +10 more
europepmc   +2 more sources

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Biochemical mechanisms in pathogenesis of infantile epileptic spasm syndrome

Seizure: European Journal of Epilepsy, 2023
The molecular mechanisms leading to infantile epileptic spasm syndrome (IESS) remain obscure. The only common factor seems to be that the spasms are restricted to a limited period of infancy, during a certain maturational state. Here the current literature regarding the biochemical mechanisms of brain maturation in IESS is reviewed, and various ...
openaire   +3 more sources

A Rare Presentation Characterized by Epileptic Spasms in ALDH7A1, Pyridox(am)ine-5′-Phosphate Oxidase, and PLPBP Deficiency

Frontiers in Genetics, 2022
Objective: To analyze the clinical feature, treatment, and prognosis of epileptic spasms (ES) in vitamin B6–dependent epilepsy, including patients with pyridoxine-dependent epilepsy (PDE) caused by ALDH7A1 mutation, pyridox(am)ine-5′-phosphate oxidase ...
Xianru Jiao, Pan Gong, Yue Niu, Yuehua Zhang, Zhixian Yang   +4 more
doaj   +1 more source

Epileptic spasms related to neuronal differentiation factor 2 (NEUROD2) mutation respond to combined vigabatrin and high dose prednisolone therapy

BMC Neurology, 2022
Background Epileptic spasms are a devastating form of early infantile epileptic encephalopathy (EIEE) with various etiologies. Early diagnosis and a shorter lead time to treatment are crucial to stop the seizures and optimize the neurodevelopmental ...
Kullasate Sakpichaisakul, Rachata Boonkrongsak, Punjama Lertbutsayanukul, Nareenart Iemwimangsa, Sommon Klumsathian, Bhakbhoom Panthan, Objoon Trachoo   +6 more
doaj   +1 more source

EPILEPTIC SPASMS

Русский журнал детской неврологии, 2015
Epileptic spasms are epileptic seizures with sudden flexion/extension or of the mixed flexion and extension type, mainly involving the proximal and truncal muscles, that are normally longer than myoclonic seizures but shorter than tonic seizures, and ...
K. Yu. Mukhin, M. B. Mironov
doaj   +1 more source