Results 1 to 10 of about 144,194 (236)

Seizure Prediction Analysis of Infantile Spasms [PDF]

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2023
Infantile spasms (IS) is a typical childhood epileptic disorder with generalized seizures. The sudden, frequent and complex characteristics of infantile spasms are the main causes of sudden death, severe comorbidities and other adverse consequences ...
Runze Zheng, Jiuwen Cao, Yuanmeng Feng, Xiaodan Zhao, Tiejia Jiang, Feng Gao   +5 more
doaj   +3 more sources

Inequities in Therapy for Infantile Spasms: A Call to Action. [PDF]

Ann Neurol, 2022
The aim of this study was to determine whether selection of treatment for children with infantile spasms (IS) varies by race/ethnicity.
Baumer FM, Mytinger JR, Neville K, Briscoe Abath C, Gutierrez CA, Numis AL, Harini C, He Z, Hussain SA, Berg AT, Chu CJ, Gaillard WD, Loddenkemper T, Pasupuleti A, Samanta D, Singh RK, Singhal NS, Wusthoff CJ, Wirrell EC, Yozawitz E, Knupp KG, Shellhaas RA, Grinspan ZM, Pediatric Epilepsy Research Consortium, National Infantile Spasms Consortium.   +24 more
europepmc   +4 more sources

EEG biomarkers for the diagnosis and treatment of infantile spasms. [PDF]

Front Neurol, 2022
Early diagnosis and treatment are critical for young children with infantile spasms (IS), as this maximizes the possibility of the best possible child-specific outcome.
Romero Milà B, Remakanthakurup Sindhu K, Mytinger JR, Shrey DW, Lopour BA.   +4 more
europepmc   +2 more sources

Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. [PDF]

J Paediatr Child Health, 2022
To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study
Dzau W, Cheng S, Snell P, Fahey M, Scheffer IE, Harvey AS, Howell KB.   +6 more
europepmc   +2 more sources

Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms [PDF]

EBioMedicine, 2022
Chunlong Mu, Shyamchand Mayengbam, Jong M Rho   +2 more
exaly   +3 more sources

Response to treatment and outcomes of infantile spasms in Down syndrome. [PDF]

Dev Med Child Neurol, 2022
To estimate the prevalence, and evaluate presentation, treatment response, treatment side effects, and long‐term seizure outcomes in all known cases of children with Down syndrome and infantile spasms on the island of Ireland.
Harvey S, Allen NM, King MD, Lynch B, Lynch SA, O'Regan M, O'Rourke D, Shahwan A, Webb D, Gorman KM, Irish Paediatric Neurology Group.   +10 more
europepmc   +2 more sources

De novo variants in MAST4 related to neurodevelopmental disorders with developmental delay and infantile spasms: Genotype-phenotype association. [PDF]

Front Mol Neurosci, 2023
Objective This study aims to prove that the de novo variants in MAST4 gene are associated with neurodevelopmental disorders (NDD) with developmental delay (DD) and infantile spasm (IS) and to determine the genotype-phenotype correlations.
Zhang X, Xiao N, Cao Y, Peng Y, Lian A, Chen Y, Wang P, Gu W, Xiao B, Yu J, Wang H, Shu L.   +11 more
europepmc   +2 more sources

Etiologic Classification of 541 Infantile Spasms Cases: A Cohort Study. [PDF]

Front Pediatr, 2022
Objective To explore the etiology of infantile spasms (IS) in a large Chinese cohort based on the United States National Infantile Spasms Consortium (NISC) classification.
Peng P, Kessi M, Mao L, He F, Zhang C, Chen C, Pang N, Yin F, Pan Z, Peng J.   +9 more
europepmc   +2 more sources

Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms. [PDF]

Neurology, 2022
Background and Objectives Standard therapies (adrenocorticotropic hormone [ACTH], oral steroids, or vigabatrin) fail to control infantile spasms in almost half of children. Early identification of nonresponders could enable rapid initiation of sequential
Yuskaitis CJ, Mytinger JR, Baumer FM, Zhang B, Liu S, Samanta D, Hussain SA, Yozawitz EG, Keator CG, Joshi C, Singh RK, Bhatia S, Bhalla S, Shellhaas R, Harini C, Pediatric Epilepsy Research Consortium.   +15 more
europepmc   +2 more sources

Targeted gut microbiota manipulation attenuates seizures in a model of infantile spasms syndrome. [PDF]

JCI Insight, 2022
Infantile spasms syndrome (IS) is a devastating early-onset epileptic encephalopathy associated with poor neurodevelopmental outcomes. When first-line treatment options, including adrenocorticotropic hormone and vigabatrin, are ineffective, the ketogenic
Mu C, Nikpoor N, Tompkins TA, Choudhary A, Wang M, Marks WN, Rho JM, Scantlebury MH, Shearer J.   +8 more
europepmc   +2 more sources