Results 91 to 100 of about 9,475 (246)

Topiramate Monotherapy in Infantile Spasm

Yonsei Medical Journal, 2006
Infantile spasm is an age-related refractory epilepsy. Topiramate is a new anticonvulsant with multiple mechanisms of action, and it may be effective for treating pediatric epilepsies. To evaluate the efficacy and tolerability of first-line topiramate treatment for infantile spasm, 20 patients received topiramate monotherapy during this study.
Yong Hoon Jun, Young Jin Hong, Young Se Kwon, Byong Kwan Son   +3 more
openaire   +3 more sources

Long‐term efficacy and safety of cannabidiol in patients with treatment‐resistant focal epilepsies treated in the Expanded Access Program

Epilepsia, EarlyView.
Open‐label CBD treatment was associated with sustained seizure reduction through 144 weeks, with a consistent safety profile in patients with treatment‐resistant focal epilepsies, regardless of epilepsy type. Abstract Objective Cannabidiol (CBD) treatment was associated with long‐term seizure reduction in patients with various treatment‐resistant ...
Anup D. Patel, Jerzy P. Szaflarski, Paul D. Lyons, Michael Boffa, Teresa Greco, Timothy B. Saurer, Karthik Rajasekaran, Kelly C. Simontacchi, Elizabeth A. Thiele   +8 more
wiley   +1 more source

A case of infantile spasms with three possibly pathogenic de novo missense variants in NF1 and GABBR1. [PDF]

Hum Genome Var, 2023
Watanabe K, Kubota K, Nakashima M, Saitsu H.   +3 more
europepmc   +1 more source

Intersection of epilepsy and cardiac health: Insights from electrocardiography and syndromic associations

Epilepsia, EarlyView.
Abstract Epilepsy is a chronic neurological condition marked by recurrent, uncontrolled seizures. Identifying comorbidities in epilepsy is critical for preventing mortality. Among these, the autonomic nervous system's role in epilepsy often manifests as cardiac disorders. Patients with epilepsy (PWE), particularly those with poorly controlled seizures,
Enes Akyuz, Feyza Sule Aslan, Tugba Eyigurbuz   +2 more
wiley   +1 more source

Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. [PDF]

J Paediatr Child Health, 2022
Dzau W, Cheng S, Snell P, Fahey M, Scheffer IE, Harvey AS, Howell KB.   +6 more
europepmc   +1 more source

Treatment of Infantile Spasms: Results of a Population‐Based Study with Vigabatrin as the First Drug for Spasms [PDF]

, 1999
Marja‐Liisa Granström, Eija Gaily, Elina Liukkonen   +2 more
openalex   +1 more source

What defines response to vagus nerve stimulation in children with drug‐resistant epilepsy? A prospective cohort study from the CONNECTiVOS collaboration

Epilepsia, EarlyView.
Abstract Objectives Responsiveness to vagus nerve stimulation (VNS) in children with drug‐resistant epilepsy (DRE) is often defined based on reduction in seizure frequency, typically at the 50% threshold, with limited consideration to the effects of therapy on seizure severity and health‐related quality of life (HRQoL). In the current report, we sought
Farbod Niazi, Karim Mithani, Hrishikesh Suresh, Simeon M. Wong, Ivanna Yau, Lyndsey McRae, Thiemo F. Dinger, James T. Rutka, Ayako Ochi, Hiroshi Otsubo, Shelly Weiss, Lauren Sham, Elizabeth Donner, Vann Chau, Aristides Hadjinicolaou, Philippe Major, Alexander G. Weil, Jignesh Tailor, Taylor J. Abel, Madison Remick, Emefa Akwayena, Dewi Schrader, Robert J. Bollo, Matthew D. Smyth, Diana Aum, Sean Lew, Shelly Wang, Toba Niazi, Jeffrey S. Raskin, Elysa Widjaja, Howard L. Weiner, Nisha Gadgil, Melissa A. LoPresti, Gregory W. Albert, Aria Fallah, Elizabeth Kerr, Mary Lou Smith, Puneet Jain, George M. Ibrahim   +38 more
wiley   +1 more source

Infantile Spasms in Down Syndrome [PDF]

, 1996
J Gordon Millichap
openalex   +1 more source

Cannabidiol attenuates epileptic phenotype and increases survival in a mouse model of developmental and epileptic encephalopathy type 1

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathy type 1 (DEE1) is a rare drug‐resistant pediatric epilepsy caused by trinucleotide repeat expansions in the X‐linked ARX gene, leading to elongation of the first polyalanine tract. It presents with early onset tonic seizures or spasms, developmental and cognition delay, and high risk of ...
Lucia Verrillo, Fabio Arturo Iannotti, Denise Drongitis, Katiuscia Martinello, Loredana Poeta, Adriano Barra, Gaetano Terrone, Sergio Fucile, Vincenzo Di Marzo, Maria Giuseppina Miano   +9 more
wiley   +1 more source

More Hormones, Less Spasms: IGF-1 as a Potential Therapy for Infantile Spasms. [PDF]

Epilepsy Curr, 2023
Dang LT.
europepmc   +1 more source