Results 111 to 120 of about 7,548,706 (340)

Dynamics of Mycobacterium tuberculosis-Specific and Nonspecific Immune Responses in Women with Tuberculosis Infection during Pregnancy

, 2022
Fregenet Tesfaye, Erik Sturegård, John Walles, Bayissa Bekele, Kidist Bobosha, Per Björkman, Marianne Jansson   +6 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Newly Named Klebsiella aerogenes (formerly Enterobacter aerogenes) Is Associated with Poor Clinical Outcomes Relative to Other Enterobacter Species in Patients with Bloodstream Infection

, 2020
Austin Wesevich, Granger Sutton, Felicia Ruffin, Lawrence P. Park, Derrick E. Fouts, Vance G. Fowler, Joshua T. Thaden   +6 more
openalex   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Clinical Significance and Functional Insights of Tesmin in Hepatocellular Carcinoma

Genetics Research
Background. Tesmin, a 60 kDa protein encoded by the metallothionein-like 5 (MTL5) gene, plays a vital role in spermatogenesis and oogenesis. Recent research has unveiled its potential involvement in malignancies, although its impact on HCC remains poorly
Lijun Cao, Lin Zhang, Siyu Liu, Xue Wang
doaj   +1 more source

Comparative infection modeling and control of COVID-19 transmission patterns in China, South Korea, Italy and Iran

, 2020
Junyu He, Guangwei Chen, Yutong Jiang, Runjie Jin, Ashton Shortridge, Susana Agustı́, Mingjun He, Jiaping Wu, Carlos M. Duarte, George Christakos   +9 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Opportunistic Infections [PDF]

Proceedings of the Royal Society of Medicine, 1965
openaire   +5 more sources

Sharps injuries and bloodborne pathogen exposure among healthcare workers: a 5-year surveillance in a teaching hospital in Singapore

Antimicrobial Stewardship & Healthcare Epidemiology
Introduction: Bloodborne pathogens’ exposures are defined as injuries to contaminated sharps and exposures to patients’ blood or body fluids continue to present risks to healthcare workers (HCWs).
Zhang Zhimin, Jin Pinhong, Toh Hui Xian, Tan Soong Geck, Molly How Kue Bien, Tan Kwee Yuen, Sheena Ong Jin Min, Lee Lai Chee, Ling Moi Lin   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source