Results 51 to 60 of about 967,020 (305)

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. [PDF]

, 2017
BackgroundChagas disease, caused by the protozoan Trypanosoma cruzi, is the leading cause of heart failure in Latin America. The clinical treatment of Chagas disease is limited to two 60 year-old drugs, nifurtimox and benznidazole, that have variable ...
Calvet, Claudia Magalhaes, Choi, Jun Yong, de Mesquita, Liliane Batista, de Souza Pereira, Mirian Claudia, Hirata, Ken, Lostracco-Johnson, Sharon, McKerrow, James H, Meuser-Batista, Marcelo, Nogueira, Alanderson, Podust, Larissa M, Roush, William R, Silva, Tatiana Araujo, Siqueira-Neto, Jair Lage, Suzuki, Brian, Thomas, Diane   +14 more
core   +3 more sources

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

TLT2 Suppresses Th1 Response by Promoting IL-6 Production in Monocyte Through JAK/STAT3 Signal Pathway in Tuberculosis

Frontiers in Immunology, 2020
The function of triggering receptor expressed on myeloid cell-like transcript 2 (TLT2) has not been characterized and their role in pulmonary tuberculosis (TB) remains unclear. In this study, we found that surface TLT2 was up-regulated in human monocytes
Jinai Li, Jinai Li, Can Cao, Can Cao, Yali Xiang, Zhongsi Hong, Zhongsi Hong, Duanman He, Haibo Zhong, Ye Liu, Ye Liu, Yongjian Wu, Yongjian Wu, Xiaobin Zheng, Xiaobin Zheng, Huan Yin, Huan Yin, Jie Zhou, Hanbin Xie, Xi Huang, Xi Huang   +20 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Screening of the central nervous system in children with invasive pulmonary aspergillosis [PDF]

, 2014
Peer reviewedPublisher ...
Broenen, Emmi, Brüggemann, Roger, Kamphuis-van Ulzen, Karin, Mavinkurve-Groothuis, Annelies, Verweij, Paul, Warris, Adilia   +5 more
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer

Molecular Cancer, 2023
Background Chimeric antigen receptor (CAR) -T cell therapy is an efficient therapeutic strategy for specific hematologic malignancies. However, positive outcomes of this novel therapy in treating solid tumors are curtailed by the immunosuppressive tumor ...
Jian Chen, Tianchuan Zhu, Guanmin Jiang, Qi Zeng, Zhijian Li, Xi Huang   +5 more
doaj   +1 more source

NECROTIZING FASCIITIS OF THE POSTERIOR CERVICAL COMPARTMENT: AN ATYPICAL CASE DUE TO STREPTOCOCCUS AGALACTIAE [PDF]

, 2012
Necrotizing fasciitis is a fulminant infection that affects the deep and superficial fascia while initially sparing the overlying skin and underlying muscle.
Abramo, Alessandro, Ferri, Emanuele, Spinato, Giacomo, Tirelli, Giancarlo   +3 more
core   +1 more source

Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events [PDF]

, 2013
Peer reviewedPublisher ...
A Matusch, A Mencacci, AE Armitage, Alistair J. P. Brown, AM Thomson, Andrea Raab, AS Ibrahim, B Spellberg, BD Corbin, CH Park, CJ Barelle, CM Lloyd, CP Smith, D Kaloriti, D Suckau, Dagmar S. Urgast, David Stead, DD Haines, DH Navarathna, DM Barry, DM MacCallum, DM MacCallum, Donna M. MacCallum, DS Urgast, ED Weinberg, EE Johnson, EH Seeley, G Kovtunovych, GD Brown, GO Latunde-Dada, H Drakesmith, H Haas, H Wang, HI Feldman, IV Ene, JC Sardi, JF McManus, JM El HageChahine, Joanna Potrykus, Jörg Feldmann, M Ogawa, MC Lorenz, MD Maines, MI Hood, MJ Marakalala, ML Pendrak, N Ramanan, N Van Rooijen, NA Gow, Nico van Rooijen, P Heymann, Q Qian, R Santos, RJ Ward, RS Almeida, S Shimma, SA Knight, Scott G. Filler, T Roemer, W Fonzi, WH Jung   +60 more
core   +4 more sources

Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study [PDF]

, 2018
Background/Aims: The hepatitis C virus (HCV) infection is important cause of chronic hepatitis. Liver biopsy is considered the gold standard for assessment of fibrosis but this procedure is an invasive procedure.
Akhan, S., Aydoǧdu, Ö., Baykam, N., Beslen, N., Bostanci, F., Candan, M., Daǧli, Ö., Demirdal, T., Duyar, E., Erdoǧan, S., Gökal, A.A., Güner, R., Gürbüz, Y., Inan, D., Kaya, A., Kaya, S., Kiliç, S., Kinikli, S., Kuruüzüm, Z., Kökoǧlu, Ö.F., Köksal, I., Leblebicioǧlu, H., Namiduru, M., Parlak, M., Sehmen, E., Tabak, F., Tarakçi, H., Turgut, Hüseyin, Ural, O., Yamazhan, T., Yilmaz, G., Yuluǧkural, Z., Önlen, Y., Özdemir, D., Özdener, F.   +34 more
core   +1 more source