Results 71 to 80 of about 4,185,931 (303)

Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization

npj Biofilms and Microbiomes, 2021
The human oral and gut commensal microbes play vital roles in the development and maintenance of immune homeostasis, while its association with susceptibility and severity of SARS-CoV-2 infection is barely understood.
Yongjian Wu, Xiaomin Cheng, Guangmin Jiang, Huishu Tang, Siqi Ming, Lantian Tang, Jiahai Lu, Cheng Guo, Hong Shan, Xi Huang   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Laboratory implementation of edge illumination X-ray phase-contrast imaging with energy-resolved detectors [PDF]

, 2015
Edge illumination (EI) X-ray phase-contrast imaging (XPCI) has potential for applications in different fields of research, including materials science, non-destructive industrial testing, small-animal imaging, and medical imaging.
A. Olivo, De Ruvo, L, Endrizzi, M., Kallon, G, SPANDRE, GLORIA, G. Spandre, Vincenzi, A, Kallon, G., A. Brez, Hagen, C. K., Olivo, A, L. De Ruvo, Basta, D, P. C. Diemoz, F. A. Vittoria, Hagen, CK, Olivo, A., C. K. Hagen, Spandre, G, Brez, A., M. Marenzana, Brez, A, DELOGU, PASQUALE, Vittoria, F. A., Marenzana, M., Bellazzini, R, Diemoz, P. C., Vincenzi, A., BELLAZZINI, RONALDO, A. Vincenzi, D. Basta, M. Endrizzi, G. Kallon, R. Bellazzini, Diemoz, PC, Vittoria, FA, Delogu, P, Endrizzi, M, Marenzana, M, De Ruvo, L., Basta, D., P. Delogu, Bellazzini R., Marenzana M., De Ruvo L., Basta D., Vincenzi A., Endrizzi M., Olivo A., Hagen C. K., Brez A., Spandre G., Vittoria F. A., Diemoz P. C., Kallon G.   +54 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Ethionamide versus ethambutol-containing first-line regimens for TB meningitis

Antimicrobial Agents and Chemotherapy
Ethionamide has emerged as an alternative to ethambutol for the treatment of tuberculous meningitis (TB meningitis). Here, we show that ethionamide- and ethambutol-containing first-line TB regimens achieved similar bactericidal activities in brain ...
Xueyi Chen, Carlos E. Ruiz-Gonzalez, Yuderleys Masias-Leon, Medha Singh, Madelynn Shambles, Charles A. Peloquin, Sanjay K. Jain   +6 more
doaj   +1 more source

Mouse model of pulmonary cavitary tuberculosis and expression of matrix metalloproteinase-9

Disease Models & Mechanisms, 2016
Cavitation is a key pathological feature of human tuberculosis (TB), and is a well-recognized risk factor for transmission of infection, relapse after treatment and the emergence of drug resistance.
Alvaro A. Ordonez, Rokeya Tasneen, Supriya Pokkali, Ziyue Xu, Paul J. Converse, Mariah H. Klunk, Daniel J. Mollura, Eric L. Nuermberger, Sanjay K. Jain   +8 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Dual energy window imaging for optimisation of P/V ratios in VP SPECT

EJNMMI Physics, 2021
Purpose Ventilation–perfusion single-photon emission computed tomography (VP SPECT) plays an important role in pulmonary embolism diagnosis. Rapid results may be obtained using same-day ventilation followed by perfusion imaging, but generally requires ...
A. G. G. Doruyter, J. L. Holness
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

HLMiller-Imaging/SlowMembraneDiffusionAnalysis: Version 1

<h2>What's Changed</h2> <ul> <li>Addcode by @HLMiller-Imaging in https://github.com/HLMiller-Imaging/SlowMembraneDiffusionAnalysis/pull/1</li> <li>TrajectoryBugFix by @HLMiller-Imaging in https://github.com/HLMiller ...
HLMiller-Imaging
core   +1 more source