Results 61 to 70 of about 967,020 (305)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The use of HEPES-buffer in the production of gallium-68 radiopharmaceuticals – time to reconsider strict pharmacopoeial limits?

EJNMMI Radiopharmacy and Chemistry, 2021
HEPES (4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) is a buffer that is used in the radiolabelling of gallium-68 compounds. The beneficial effects of HEPES on molar activity in bioconjugates have been well described. Current strict regulations on
Jannie le Roux, Janke Kleynhans, Sietske Rubow   +2 more
doaj   +1 more source

Subacute Sclerosing Panencephalitis of the Brainstem as a Clinical Entity. [PDF]

, 2017
Subacute sclerosing panencephalitis (SSPE) is a rare progressive neurological disorder of early adolescence caused by persistent infection of the measles virus, which remains prevalent worldwide despite an effective vaccine. SSPE is a devastating disease
Ciacci, Joseph D, Upadhyayula, Pavan S, Yang, Jason, Yue, John K   +3 more
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis

Nature Communications
Mycobacterium tuberculosis establishes within host cells by inducing anti-apoptotic Bcl-2 family proteins, triggering necrosis, inflammation, and fibrosis.
Medha Singh, Mona O. Sarhan, Nerketa N. L. Damiba, Alok K. Singh, Andres Villabona-Rueda, Oscar J. Nino-Meza, Xueyi Chen, Yuderleys Masias-Leon, Carlos E. Ruiz-Gonzalez, Alvaro A. Ordonez, Franco R. D’Alessio, Eric O. Aboagye, Laurence S. Carroll, Sanjay K. Jain   +13 more
doaj   +1 more source

Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

iScience, 2020
Summary: Many of the SARS-CoV-2 proteins have related counterparts across the Severe Acute Respiratory Syndrome (SARS-CoV) family. One such protein is non-structural protein 9 (Nsp9), which is thought to mediate viral replication, overall virulence, and ...
Dene R. Littler, Benjamin S. Gully, Rhys N. Colson, Jamie Rossjohn   +3 more
doaj   +1 more source

Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization

npj Biofilms and Microbiomes, 2021
The human oral and gut commensal microbes play vital roles in the development and maintenance of immune homeostasis, while its association with susceptibility and severity of SARS-CoV-2 infection is barely understood.
Yongjian Wu, Xiaomin Cheng, Guangmin Jiang, Huishu Tang, Siqi Ming, Lantian Tang, Jiahai Lu, Cheng Guo, Hong Shan, Xi Huang   +9 more
doaj   +1 more source

Combination antiretroviral therapy improves cognitive performance and functional connectivity in treatment-naïve HIV-infected individuals. [PDF]

, 2017
Our study aimed to investigate the short-term effect of combination antiretroviral therapy (cART) on cognitive performance and functional and structural connectivity and their relationship to plasma levels of antiretroviral (ARV) drugs.
Arduino, Roberto C, Luque, Amneris, Ma, Qing, Mapstone, Mark, Miller, Eric, Qiu, Xing, Schifitto, Giovanni, Tivarus, Madalina, Wang, Lu, Weber, Miriam, Zhong, Jianhui, Zhuang, Yuchuan   +11 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source