Results 91 to 100 of about 967,020 (305)

Spatial imaging of Zn and other elements in Huanglongbing-affected grapefruit by synchrotron-based micro X-ray fluorescence investigation [PDF]

, 2014
Huanglongbing (HLB) is a highly destructive, fast-spreading disease of citrus, causing substantial economic losses to the citrus industry worldwide. Nutrient levels and their cellular distribution patterns in stems and leaves of grapefruit were analysed ...
Brown, PH, He, Z, Labavitch, JM, Lu, L, Tian, S, Webb, SM, Yang, X   +6 more
core   +2 more sources

Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies. [PDF]

, 2020
Preventing bacterial infections from becoming the leading cause of death by the year 2050 requires the development of novel, infection-control strategies, building heavily on biomaterials science, including nanotechnology.
Busscher, Henk J., Frijlink, Hendrik W., Grainger, David W., Hinrichs, Wouter L.J., Jutte, Paul, Kates, Stephen, Liu, Jian, Liu, Jianfeng, Parvizi, Javad, Rotello, Vincent M., Schaer, Thomas P., Shi, Linqi, Shi, Rui, van der Mei, Henny C., van Kooten, Theo G., Williams, Dustin, Woudstra, Willem   +16 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy

Frontiers in Immunology, 2019
The homing molecule, L-selectin (CD62L), is commonly used as a T cell activation marker, since expression is downregulated following engagement of the T cell receptor.
H. Angharad Watson, Ruban R. P. Durairaj, Julia Ohme, Markella Alatsatianos, Hanan Almutairi, Rebar N. Mohammed, Miriam Vigar, Sophie G. Reed, Stephen J. Paisey, Christopher Marshall, Awen Gallimore, Awen Gallimore, Ann Ager, Ann Ager   +13 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Immune- and nonimmune-compartment-specific interferon responses are critical determinants of herpes simplex virus-induced generalized infections and acute liver failure [PDF]

, 2016
The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis.
Leib, David A, Parker, George A, Parker, Zachary M, Pasieka, Tracy Jo   +3 more
core   +3 more sources

Imaging spinal infection

Radiology of Infectious Diseases, 2016
AbstractInfection involving the vertebral column, including the bone, intervertebral disk, and paravertebral soft tissues is critical and early diagnosis and directed treatment is paramount. Different infectious organisms present with variable imaging characteristics, which when examined in conjunction with the clinical history, can facilitate early ...
Acharya, Jay, Gibbs, Wende N.
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Engineered nanovesicles as a DC vaccine to enhance the antitumor efficacy of CAR-T cells against solid tumors

Journal of Nanobiotechnology
Background Despite the success of chimeric antigen receptor (CAR)-T cell therapy in hematological malignancies, its efficacy against solid tumors like non-small cell lung cancer (NSCLC) remains limited due to the immunosuppressive tumor microenvironment (
Shaolong Ju, Tianchuan Zhu, Shoudeng Chen, Yongjian Wu, Xi Huang   +4 more
doaj   +1 more source

A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro [PDF]

, 2015
The ubiquitin–proteasome system is an essential cellular process that plays a fundamental role in the regulation of protein stability. This pathway is tightly controlled by a sequential cascade of enzymatic steps that culminates in the formation of a ...
Boutell, Chris, Davido, David J.
core   +2 more sources