Results 101 to 110 of about 4,185,931 (303)

Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer

Journal of Experimental & Clinical Cancer Research
Background High infiltration of tumor-associated macrophages (TAMs) is associated with tumor promotion and immunosuppression. The triggering receptor expressed on myeloid cells 2 (TREM2) is emerged as a key immunosuppressive regulator for TAMs, however ...
Qiaohua Wang, Yongjian Wu, Guanmin Jiang, Xi Huang   +3 more
doaj   +1 more source

LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration

Nature Communications, 2016
Lymphoid progenitors migrate from the bone marrow into the thymus to give rise to T and NK cell lineages. Here the authors characterize a lymphotoxin receptor beta-dependent population of thymic endothelial cells that guide lymphoid progenitor homing in ...
Yaoyao Shi, Weiwei Wu, Qian Chai, Qingqing Li, Yu Hou, Huan Xia, Boyang Ren, Hairong Xu, Xiaohuan Guo, Caiwei Jin, Mengjie Lv, Zhongnan Wang, Yang-Xin Fu, Mingzhao Zhu   +13 more
doaj   +1 more source

Role of imaging in CNS infections.

Indian journal of pathology & microbiology, 2022
Neuroinfections are seen in both adults and children. These can result in serious morbidity and if left untreated and/or associated with comorbidities can be life threatening. Cross-sectional imaging like computed tomography (CT) and magnetic resonance imaging (MRI) are advised by the clinicians for the diagnosing, confirmation of the diagnosis, assess
G G Sharath Kumar, Chaitra Parameshwara Adiga, Prakash P Iyer, Lakshmikanth N Goolahally   +3 more
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Disulfiram-loaded nanovesicles hydrogel promotes healing of diabetic wound

Journal of Translational Medicine
Background Traditional methods for treating diabetic wounds are limited in effectiveness because of their long healing times, the risk of immune rejection, and susceptibility to infection. Suppressing neutrophil extracellular traps (NETs) is an effective
Xingzi Sun, Hanxi Ding, Xingyu Li, Yongjian Wu, Xi Huang   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Targeting apoptosis for optical imaging of infection [PDF]

, 2012
PURPOSE: Infection is ubiquitous and a major cause of morbidity and mortality. The most reliable method for localizing infection requires radiolabeling autologous white blood cells ex vivo.
Thakur, Mathew L, Gray, Brian D, Wickstrom, Eric, Pak, Koon Y, Paudyal, Bishnuhari, Devakumar, Devadhas, Zhang, Kaijun, Covarrubias, Maria Y, Cheng, Changpo   +8 more
core  

PET/CT imaging of Mycobacterium tuberculosis infection. [PDF]

, 2016
Tuberculosis has a high morbidity and mortality worldwide. Mycobacterium tuberculosis (Mtb) has a complex pathophysiology; it is an aerobic bacillus capable of surviving in anaerobic conditions in a latent state for a very long time before reactivation ...
de Vries, Erik, Alfred O. Ankrah, Mike M. Sathekge, Dierckx, Rudi, Sathekge, M. M., Rudi A. J. O. Dierckx, de Vries, Erik; id_orcid, Werf, van der, Tjip, Glaudemans, Andor W.J.M., Glaudemans, Andor W.J.M.; id_orcid, Ankrah, Alfred, Tjip S. van der Werf, Erik F. J. de Vries, Andor W. J. M. Glaudemans   +13 more
core   +2 more sources

Lipid alterations in hereditary peripheral neuropathies: common mechanisms in disease heterogeneity?

Molecular Neurodegeneration
While the impact of lipid alterations on central nervous system disorders is well-studied, increasing evidence indicates that lipids also play an important role in the pathology of hereditary peripheral neuropathies (HPN).
Koen Kuipers, Sam Vanherle, Kirsten Poelmans, Esther Wolfs, Jeroen Bogie, Tim Vangansewinkel   +5 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source