Results 111 to 120 of about 4,185,931 (303)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Imaging of Pulmonary Fungal Infection
Nippon Ishinkin Gakkai Zasshi, 2009 肺の真菌感染症は，免疫能が正常な宿主に発症する特殊な肺感染症でもあるが，免疫不全患者に発症する日和見感染のなかで重要な位置を占めている．免疫不全患者が増加している現在において，その早期診断は患者の予後を左右し，非常に重要である．しかし，血清学的・細菌学的検査でも診断が困難なことが少なくなく，肺真菌症における画像診断の役割は大きい．胸部単純写真では，病変の存在を指摘できないことがあり，質的診断も極めて困難であり，CTによる診断が必要である．画像所見の特徴としては，結節・腫瘤影が高頻度に認められることが挙げられるが，ニューモシスチス肺炎は例外で，びまん性すりガラス影を特徴とする．本稿では，代表的な肺真菌症の画像所見について解説し，さらに免疫不全患者における他疾患との鑑別診断についても言及する．
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Integrated system for ultrasonic, elasticity and photoacoustic imaging [PDF]
, 2008 textBy integrating three complementary imaging techniques - ultrasound, elasticity and photoacoustic imaging, a hybrid imaging system utilizing an array transducer is proposed for various biomedical imaging applications including cancer detection ...
Park, Suhyun, 1977-
core
Antimicrobial peptide for bacterial infection imaging: first case reported in Brazil. [PDF]
Einstein (Sao Paulo), 2023 Nogueira SA +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Expert opinions in nuclear medicine: Finding the "holy grail" in infection imaging. [PDF]
Front Med (Lausanne), 2023 Glaudemans AWJM, Gheysens O.
europepmc +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Intestinal parasitic infection.
, 2008 In general, gastrointestinal tract is the primary involvement site of parasites during their life cycle. In this article, we will describe amebiasis, ascariasis, and anisakiasis among the many common intestinal parasitic diseases.
김기황, 박미숙
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