Results 111 to 120 of about 1,589,038 (397)

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Conserved Cysteines of a Putative Zinc Finger Motif in P48 Are Important for the Nuclear Egress of Nucleocapsids and the Envelopment of Occlusion-Derived Virions

open access: yesViruses
The open reading frame 103 (p48) of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is one of the 38 core baculovirus genes. p48 has been shown to be essential for the production of infectious budded virions (BVs), nuclear egress of ...
Xiaoyan Ma   +4 more
doaj   +1 more source

Combined Effects of Elevated pCO2 and Warming Facilitate Cyanophage Infections

open access: yesFrontiers in Microbiology, 2017
Elevated pCO2 and warming are generally expected to influence cyanobacterial growth, and may promote the formation of blooms. Yet, both climate change factors may also influence cyanobacterial mortality by favoring pathogens, such as viruses, which will ...
Kai Cheng   +4 more
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Effects of vaccination on antibody level and duration of viral shedding in Omicron patients

open access: yesJournal of Infection in Developing Countries
Introduction: We compared the clinical characteristics of vaccinated and non-vaccinated Omicron patients in order to provide a reference for the clinical diagnosis and treatment of coronavirus disease 2019 (COVID-19).
Zhen Wan   +7 more
doaj   +1 more source

Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]

open access: yes, 2014
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis   +1 more
core   +4 more sources

Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease

open access: yesEmerging Infectious Diseases, 2014
We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease.
J. Douet   +11 more
semanticscholar   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission [PDF]

open access: yes, 2010
Hepatitis C virus (HCV) can initiate infection by cell-free particle and cell-cell contact-dependent transmission. In this study we use a novel infectious coculture system to examine these alternative modes of infection.
Balfe, Peter   +12 more
core   +4 more sources

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