Results 61 to 70 of about 505,151 (313)
Journal of Bioinformatics and Genomics, 2020 This work aims to develop a novel computational framework for automatic or semi-automatic modeling of gene regulatory networks, in which possible connections between genetic structural knowledge and other forms of knowledge available about GRNs can be ...
López, J. +3 more
doaj +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Informal Logic, 2011 A conclusion follows from given premisses if and only if an acceptable counterfactual-supporting covering generalization of the argument rules out, either definitively or with some modal qualification, simultaneous acceptability of the premisses and non-accepta-bility of the conclusion, even though it does not rule out acceptability of the premisses ...
openaire +4 more sources
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Studies in Digital Heritage, 2017 It is common for cultural heritage applications to use spatial and/or spectral data for documentation, analysis and visualisation. Knowledge on data requirements coming from the cultural heritage application and technical alternatives to generate the ...
Stefanie Wefers +3 more
doaj +1 more source
Ensemble Inference and Inferability of Gene Regulatory Networks
PLoS ONE, 2014 The inference of gene regulatory network (GRN) from gene expression data is an unsolved problem of great importance. This inference has been stated, though not proven, to be underdetermined implying that there could be many equivalent (indistinguishable) solutions. Motivated by this fundamental limitation, we have developed new framework and algorithm,
Ud-Dean Minhaz, Gunawan Rudiyanto
openaire +7 more sources
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
Critical Thinking and Informal Logic: Neuropsychological Perspectives
Informal Logic, 2011 This article challenges the common view that improvements in critical thinking are best pursued by investigations in informal logic. From the perspective of research in psychology and neuroscience, hu-man inference is a process that is multimodal ...
Paul Thagard
doaj +1 more source