Results 61 to 70 of about 518,510 (312)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Unifying spatial and social network analysis in disease ecology.

Journal of Animal Ecology, 2020
Social network analysis has achieved remarkable popularity in disease ecology, and is sometimes carried out without investigating spatial heterogeneity.
Gregory F. Albery, Lucinda Kirkpatrick, J. A. Firth, S. Bansal   +3 more
semanticscholar   +1 more source

Accounting for spatial sampling patterns in Bayesian phylogeography

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Statistical phylogeography has led to substantial progress in our understanding of the pace and means by which organisms colonize their habitats.
S. Guindon, N. de Maio
semanticscholar   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Deep Compositional Spatial Models [PDF]

Journal of the American Statistical Association, 2019
Spatial processes with nonstationary and anisotropic covariance structure are often used when modeling, analyzing, and predicting complex environmental phenomena. Such processes may often be expressed as ones that have stationary and isotropic covariance
A. Zammit‐Mangion, T. L. J. Ng, Quan Vu, M. Filippone   +3 more
semanticscholar   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Reconstructing angular light field by learning spatial features from quadrilateral epipolar geometry

Scientific Reports
Recent research on dense multi-view image reconstruction has attracted considerable attention, due to its enhancement of applications such as 3D reconstruction, de-occlusion, depth sensing, saliency detection, and prominent object identification.
Ebrahem Elkady, Ahmed Salem, Hyun-Soo Kang, Jae-Won Suh   +3 more
doaj   +1 more source

KSRV: a Kernel PCA-Based framework for inferring spatial RNA velocity at single-cell resolution

Frontiers in Genetics
Understanding the temporal dynamics of gene expression within spatial contexts is essential for deciphering cellular differentiation. RNA velocity, which estimates the future state of gene expression by distinguishing spliced from unspliced mRNA, offers ...
Yan He, Yan He, Jian Jiang, Jian Jiang, Huahai Qiu, Huahai Qiu, Ya-Zhou Shi, Ya-Zhou Shi, Ben-Gong Zhang, Ben-Gong Zhang   +9 more
doaj   +1 more source