Results 51 to 60 of about 518,510 (312)
Hierarchical development of dominance through the winner-loser effect and socio-spatial structure.
PLoS ONE, 2022 In many groups of animals the dominance hierarchy is linear. What mechanisms underlie this linearity of the dominance hierarchy is under debate. Linearity is often attributed to cognitively sophisticated processes, such as transitive inference and ...
Erik van Haeringen, Charlotte Hemelrijk
doaj +1 more source
PLoS Computational Biology, 2022 Quantitative stochastic models of gene regulatory networks are important tools for studying cellular regulation. Such models can be formulated at many different levels of fidelity. A practical challenge is to determine what model fidelity to use in order
Adrien Coulier +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Fast and flexible estimation of effective migration surfaces
eLife, 2021 Spatial population genetic data often exhibits ‘isolation-by-distance,’ where genetic similarity tends to decrease as individuals become more geographically distant.
Joseph Marcus +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Journal of Geophysical Research: Solid Earth, 1989 Fracturing in fine‐grained homogeneous granite during triaxial deformation was investigated by measuring the spatial and temporal variations of elastic wave velocities. Velocities along 20 ray paths were measured with 12 piezoelectric transducers attached to a sample under confining pressures up to 400 MPa.
openaire +2 more sources
IET Systems BiologySpatially resolved transcriptomics technologies potentially provide the extra spatial position information and tissue image to better infer spatial cell–cell interactions (CCIs) in processes such as tissue homeostasis, development, and disease ...
Han Zhang +9 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
High-Order Composite Likelihood Inference for Max-Stable Distributions and Processes [PDF]
, 2014 In multivariate or spatial extremes, inference for max-stable processes observed at a large collection of points is a very challenging problem and current approaches typically rely on less expensive composite likelihoods constructed from small subsets of
S. Castruccio, Raphael Huser, M. Genton
semanticscholar +1 more source
Pairwise interaction point processes for modelling bivariate spatial point patterns in the presence of interaction uncertainty [PDF]
, 2015 Current ecological research seeks to understand the mechanisms that sustain biodiversity and allow a large number of species to coexist. Coexistence concerns inter-individual interactions. Consequently, there is an interest in identifying and quantifying
Nightingale, Glenna Faith +5 more
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