Active integration of glutamatergic input to the inferior olive generates bidirectional postsynaptic potentials. [PDF]
J Physiol, 2017 We establish experimental preparations for optogenetic investigation of glutamatergic input to the inferior olive. Neurones in the principal olivary nucleus receive monosynaptic extra‐somatic glutamatergic input from the neocortex.
Garden DL, Rinaldi A, Nolan MF.
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Progressive limb ataxia following inferior olive lesions
The Journal of Physiology, 2013 Key points The inferior olive (IO) provides climbing fibre input to the cerebellum. Kainic acid lesions of rostral IO of the cat produce several distinct movement deficits. Vestibular disturbances are apparent the first few days after injection but rapidly recover.
K. Horn, Aman Deep, A. Gibson
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Delayed Complex Spike Response Evoked by Conditioned Stimulus Encodes Movement Onset Time and Is Determined by Intrinsic Inferior Olive Properties [PDF]
Frontiers in Systems Neuroscience, 2019 Recent studies demonstrate that after classical conditioning the conditioned stimulus (CS) triggers a delayed complex spike. This new finding revolutionizes our view on the role of complex spike activity.
Yasmin Yarden-Rabinowitz +3 more
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Synaptically induced long-term modulation of electrical coupling in the inferior olive. [PDF]
Neuron, 2014 Summary Electrical coupling mediated by gap junctions is widespread in the mammalian CNS, and the interplay between chemical and electrical synapses on the millisecond timescale is crucial for determining patterns of synchrony in many neural circuits ...
Mathy A, Clark BA, Häusser M.
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Imaging Subthreshold Voltage Oscillation With Cellular Resolution in the Inferior Olive in vitro [PDF]
Frontiers in Cellular Neuroscience, 2020 Voltage imaging with cellular resolution in mammalian brain slices is still a challenging task. Here, we describe and validate a method for delivery of the voltage-sensitive dye ANNINE-6plus (A6+) into tissue for voltage imaging that results in higher ...
Kevin Dorgans +2 more
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Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network [PDF]
eLife, 2020 The electrical connectivity in the inferior olive (IO) nucleus plays an important role in generating well-timed spiking activity. Here we combined electrophysiological and computational approaches to assess the functional organization of the IO nucleus ...
Yaara Lefler +4 more
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Frontiers in Computational Neuroscience, 2014 The cerebellum is known to play a critical role in learning relevant patterns of activity for adaptive motor control, but the underlying network mechanisms are only partly understood.
Niceto Rafael Luque +6 more
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Synchronicity and Rhythmicity of Purkinje Cell Firing during Generalized Spike-and-Wave Discharges in a Natural Mouse Model of Absence Epilepsy [PDF]
Frontiers in Cellular Neuroscience, 2017 Absence epilepsy is characterized by the occurrence of generalized spike and wave discharges (GSWDs) in electrocorticographical (ECoG) recordings representing oscillatory activity in thalamocortical networks.
Lieke Kros +9 more
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Impaired Motor Learning in a Disorder of the Inferior Olive: Is the Cerebellum Confused? [PDF]
Cerebellum, 2017 Shaikh AG, Wong AL, Optican LM, Zee DS.
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Changes in Cerebellar Multiunit Activity Associated with Ventrolateral Striatal Injury During Spontaneous Motor Behavior [PDF]
Medical SciencesBackground: Parkinsonism entails pronounced basal ganglia dysfunction, but emerging research suggests that broader subcortical networks, specifically the cerebellum, play a vital role in functional motor compensation following circuit-level ...
Irais Viveros-Martínez +6 more
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