Results 31 to 40 of about 259,314 (253)

Extended blastocyst culture improves DNA yield in non-invasive preimplantation genetic testing for aneuploidy but diagnostic specificity remains limited

Scientific Reports
Non-invasive preimplantation genetic testing for aneuploidy (niPGT-A), which analyzes cell-free DNA (cfDNA) from spent culture media (SCM), has emerged as a proposed alternative to trophectoderm (TE) biopsy in in vitro fertilization (IVF).
Ting-Feng Wu, Chun-I Lee, Hui-Hsin Shih, En-Hui Cheng, Chun-Chia Huang, Tsung-Hsien Lee, Maw-Sheng Lee, Pin-Yao Lin   +7 more
doaj   +1 more source

The Pregnancy Outcomes of Day 2 versus Day 3 Embryo Transfer: A Cross-Sectional Study [PDF]

International Journal of Fertility and Sterility, 2007
Background: The objective was to evaluate whether extending the embryo culture period from 2 to 3 days would yield a more optimal selection of viable embryos, thereby increasing the pregnancy rate.Materials and Methods: We have retrospectively analyzed ...
Mahnaz Ashrafi, Kiandokht Kiani, Elahe Mirzaagha, Fatemeh Shabani   +3 more
doaj   +1 more source

Successful Outcome Following Hysteroscopic Septoplasty in a Woman with Seven Consecutive Pregnancy Losses

Fertility & Reproduction, 2021
Anomalies of the reproductive tract are common and present in about 3%–5% of the general population and in about 3% of infertile women. In general, they are asymptomatic, but they can also be associated with recurrent abortions or infertility.
Jesmine Banu, Mumtahena Amir, Shakeela Ishrat, Sadia Afrin Munmun, Nighat Sultana   +4 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Developmental potential of oocytes fertilized by conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) after cryopreservation and mesometrial autotransplantation of rabbit ovarian tissue

Animal, 2008
Objective: To evaluate mesometrial transplantation of frozen-thawed ovarian tissue in rabbit and to choose the optimized fertilization method for oocytes retrieved from grafts by investigating the capability of oocyte fertilization and further ...
C. Lan, D. Xiaohui, F. Qingzhao, X. Anran, H. Chun-yan, Y. Hongling, Y. Xuan   +6 more
doaj   +1 more source

Blastocyst Morphology Based on Uniform Time-Point Assessments is Correlated With Mosaic Levels in Embryos

Frontiers in Genetics, 2021
Avoiding aneuploid embryo transfers has been shown to improve pregnancy outcomes in patients with implantation failure and pregnancy loss. This retrospective cohort study aims to analyze the correlation of time-lapse (TL)-based variables and numeric ...
Chien-Hong Chen, Chun-I Lee, Chun-I Lee, Chun-I Lee, Chun-Chia Huang, Hsiu-Hui Chen, Shu-Ting Ho, En-Hui Cheng, Pin‐Yao Lin, Chung-I Chen, Tsung-Hsien Lee, Tsung-Hsien Lee, Tsung-Hsien Lee, Maw-Sheng Lee, Maw-Sheng Lee, Maw-Sheng Lee   +15 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Infertility and assisted reproductive technologies in Serbia [PDF]

, 2022
Infertility is a significant challenge, both on individual and macro levels. The overall aim of this paper is to contribute to better understanding infertility in Serbia by analysing relevant policies and programmes, data on the epidemiology of ...
Sedlecky, Katarina, Rašević, Mirjana, Mirjana Rasevic, Katarina Sedlecky, Katarina Sedlecky   +4 more
core   +1 more source

The Effects of Cabergoline Compared to Dienogest in Women with Symptomatic Endometrioma

Fertility & Reproduction, 2021
Background: New vessel formation or neovascularization has been recognized as a feature of endometriosis. Treatment with cabergoline suppresses cell proliferation and vascular-endothelial-growth-factor-mediated angiogenesis, thereby promoting regression ...
Mehnaz Mustary Shume, Jesmine Banu, Shakeela Ishrat, Serajoom Munira, Muhammad Jasim Uddin, Sabiha Sultana   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source