Results 41 to 50 of about 250,861 (303)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Use of a Hysteroscopic Tissue Removal System for Revision of Cesarean Scar Isthmocele: A Case Report

Case Reports in Obstetrics and Gynecology
Cesarean scar isthmocele (CSI) is a defect in the anterior myometrial wall of the uterine isthmus, at the site of a previous cesarean scar, and can be associated with menorrhagia in the form of prolonged menstrual bleeding or spotting, dysmenorrhea, and ...
Shahryar K. Kavoussi, Amy S. Esqueda, Krista London, Sarah M. Compton, Ellen Jatinen, Kelsey Cathcart   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

“It’s a big deal, being given a person” – a study of the links between infertility and adoption [PDF]

, 2015
This study was commissioned and funded by Family Care and undertaken by Jo Ward and Joe Smeeton, both Principal Lecturers at Nottingham Trent University.
Smeeton, J., Ward, J, Ward, J., Smeeton, J   +3 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Embryos With “No Result” After PGT-A: A Retrospective Analysis of Causative Factors

Obstetrics and Gynecology International
Conclusion: No clear embryo-related risk factors could be elucidated; however, the biopsy procedure and sample cellularity seem to be crucial components.
Anastasia Salame, Elias M. Dahdouh, Mokhamad Zhaffal, Rania Aljafari, Arya Muraleekrishnan, Aparna Bajpai, Shabin Kainoth, Leyla Depret Bixio, Michael Fakih   +8 more
doaj   +1 more source

Comparison of Day 14 Serum Progesterone Level Based on Pregnancy Outcome in Patients Undergoing Intracytoplasmic Sperm Injection Cycles [PDF]

Journal of Kerman University of Medical Sciences, 2015
Background & Aims: Serum progesterone level (as early as 4 weeks gestation) reflects the relation between embryo and corpus luteum. The purpose of the present study was to compare serum progesterone level on day 14 after embryo transfer among 3 groups of
Marzieh Mehrafza, Azadeh Raouf, Talieh Rahimian, Zahra Nikpouri, Parvaneh Abdollahian, Ahmad Hosseini   +5 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Evaluation of the Osteogenic Potential of Apigenin via Inducing Autophagy: An In Vitro Study

Stem Cells International
The present study aimed to evaluate the effect of apigenin (Api) on the osteogenic differentiation of adipose tissue-derived mesenchymal stem cells (ASCs) by stimulating autophagy.
Mozafar Khazaei, Amirmohammad Khodaei, Maryam Bozorgi, Mohammad Rasool Khazaei, Azam Bozorgi   +4 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source