Results 41 to 50 of about 259,314 (253)
Effects of Infertility Insurance Mandates on Fertility [PDF]
Infertility currently affects over 6 million individuals in the United States. While most health insurance plans nationwide do not cover infertility diagnoses or treatments, to date fifteen states have enacted some form of infertility insurance mandate ...
Lucie Schmidt
core +2 more sources
Improved clinical outcomes with a modified warming protocol in donor oocyte cycles
Journal of Ovarian ResearchBackground Recent studies have attempted to improve laboratory efficiency while preserving clinical outcomes by shortening the time to warm cryopreserved embryos, though it is still unclear for oocytes.
Chun-I Lee +8 more
doaj +1 more source
International Journal of Reproductive BioMedicine, 2023 Background: Endometriosis is a challenging gynecological disease and a debilitating condition that profoundly affects the individual's quality of life.
Roya Padmehr +7 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The association between sperm aneuploidy and male infertility: Screening, aetiology and possible routes to alternative therapy [PDF]
, 2003 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.One in six couples wishing to start a family are infertile.
Tempest, Helen Ghislaine
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Use of a Hysteroscopic Tissue Removal System for Revision of Cesarean Scar Isthmocele: A Case Report
Case Reports in Obstetrics and GynecologyCesarean scar isthmocele (CSI) is a defect in the anterior myometrial wall of the uterine isthmus, at the site of a previous cesarean scar, and can be associated with menorrhagia in the form of prolonged menstrual bleeding or spotting, dysmenorrhea, and ...
Shahryar K. Kavoussi +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Infertility associated with adenomyosis. Literature review
, 2023 Background. Infertility tends to become one more modern pandemic. According to some estimates, the percentage of infertile couples varies between 10–25% (48–180 million).
Ebecha K. Barinova +6 more
core +1 more source
Embryos With “No Result” After PGT-A: A Retrospective Analysis of Causative Factors
Obstetrics and Gynecology InternationalConclusion: No clear embryo-related risk factors could be elucidated; however, the biopsy procedure and sample cellularity seem to be crucial components.
Anastasia Salame +8 more
doaj +1 more source