Results 1 to 10 of about 85,115,453 (207)

Preimplantation genetic testing for aneuploidy: challenges in clinical practice

Human Genomics, 2022
Preimplantation genetic testing for aneuploidy (PGT-A) has been used widely during in vitro fertilization procedures in assisted reproductive centers throughout the world.
Hui Yang, Andrew Thomas DeWan, Mayur M. Desai, Sten H. Vermund   +3 more
doaj   +3 more sources

Preimplantation genetic testing for aneuploidy in uterus transplant patients

Therapeutic Advances in Reproductive Health, 2021
Uterus transplantation is an emerging treatment for uterine factor infertility. In vitro fertilization with cryopreservation of embryos prior is required before a patient can be listed for transplant.
Rhea Chattopadhyay, Elliott Richards, Valerie Libby, Rebecca Flyckt   +3 more
doaj   +3 more sources

Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in Taiwan

Fertility & Reproduction, 2023
Noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) using cell-free DNA (cfDNA) present in the spent blastocyst medium (SBM) of human blastocysts has emerged as an alternative for classical preimplantation genetic testing for aneuploidy (
Chun-Kai Chen, Wei-Han Huang, Tiencheng Arthur Chang, Kuang-Han Chao, Wang-Fung Chiang, Hsin-Yi Yeh, Szu-Yu Shen   +6 more
doaj   +2 more sources

Conventional in vitro fertilization enhances preimplantation genetic testing for aneuploidy outcomes in couples with non-male factor infertility [PDF]

Scientific Reports
While extensive research has compared ICSI and c-IVF in general ART outcomes, limited evidence exists regarding their relative efficacy and safety in PGT-A cycles.
Xiaolan Li, Qian Li, Yajie Chang, Shujing He, Yanfang Wang, Xiaoyan Liang, Zhiqiang Zhang   +6 more
doaj   +2 more sources

Embryo ploidy status classification through computer-assisted morphology assessmentAJOG MFM at a Glance

AJOG Global Reports, 2023
BACKGROUND: Preimplantation genetic testing for aneuploidy has been proven to be effective in determining the embryo's chromosomal or ploidy status. The test requires a biopsy of embryonic cells on day 3, 5, or 6 from which complete information on the ...
Gunawan Bondan Danardono, SKom, BEng, Nining Handayani, DVM, MBiomed, Claudio Michael Louis, SKom, BEng, Arie Adrianus Polim, MD, SpOG, DMAS, MBHRE, Batara Sirait, SpOG, Gusti Periastiningrum, SSi, Szeifoul Afadlal, PhD, Arief Boediono, DVM, Ivan Sini, MD, FRANZOG, GDRM, MMIS, SpOG   +8 more
doaj   +1 more source

A comprehensive preimplantation genetic testing approach for SEA-type α-thalassemia by fluorescent gap-polymerase chain reaction combined with haplotype analysis

Frontiers in Genetics, 2023
Introduction: This study aimed to evaluate the feasibility and necessity of using fluorescence Gap-polymerase chain reaction combined with haplotype analysis in preimplantation genetic testing for SEA-type α-thalassemia.Methods: A total of 26 ...
Jing Wang, Yuanlin Ma, Jing Guo, Rong Li, Canquan Zhou, Yanwen Xu   +5 more
doaj   +1 more source

Preimplantation Genetic Testing for Single Gene Conditions and Aneuploidy

Fertility & Reproduction, 2023
It is now over 30 years since the first pregnancies and live births following IVF, embryo biopsy and preimplantation genetic testing (PGT) were reported in 1990. Since then, methods for genetic analysis at the single-cell level have evolved alongside the
Alan Handyside
doaj   +1 more source

Application of machine learning to predict aneuploidy and mosaicism in embryos from in vitro fertilization cyclesAJOG Global Reports at a Glance

AJOG Global Reports, 2022
BACKGROUND: The factors associated with embryo aneuploidy have been extensively studied. Mostly maternal age and to a lesser extent male factor and ovarian stimulation have been related to the occurrence of chromosomal alterations in the embryo.
José A. Ortiz, PhD, Ruth Morales, PhD, Belén Lledó, PhD, Juan A. Vicente, PhD, Julio González, PhD, Eva M. García-Hernández, PhD, Alba Cascales, MSc, Jorge Ten, PhD, Andrea Bernabeu, PhD, MD, Rafael Bernabeu, PhD, MD   +9 more
doaj   +1 more source

Pre-implantation Genetic Testing for Aneuploidy (PGT-A)

Thai Journal of Obstetrics and Gynaecology, 2020
Preimplantation genetic diagnosis (PGD) or embryo selection was first performed in 1989 using PCR for gender selection to avoid X-linked recessive disorder. However, there was a misdiagnosis due to allele drop out (ADO). Therefore, fluorescent in situ
Wirawit Piyamongkol
doaj   +1 more source

Evolution and utility of preimplantation genetic testing for monogenic disorders in assisted reproduction - A narrative review

Journal of Human Reproductive Sciences, 2021
Preimplantation genetic testing (PGT) for monogenic disorders and assisted reproductive technology have evolved and progressed in tandem. PGT started with single-cell polymerase chain reaction (PCR) followed by fluorescent in situ hybridisation for a ...
Firuza R Parikh, Arundhati S Athalye, Dhananjaya K Kulkarni, Rupesh R Sanap, Suresh B Dhumal, Dhanashree J Warang, Dattatray J Naik, Prochi F Madon   +7 more
doaj   +1 more source