Results 41 to 50 of about 4,054 (204)

Comparison of chromosomal status in reserved multiple displacement amplification products of embryos that resulted in miscarriages or live births: a blinded, nonselection case–control study

BMC Medical Genomics, 2022
Objective To analyze chromosomal status in reserved multiple displacement amplification (MDA) products of embryos that result in miscarriages or live births.
Guoxia Yang, Yan Xu, Yanhong Zeng, Jing Guo, Jiafu Pan, Canquan Zhou, Yanwen Xu   +6 more
doaj   +1 more source

Preimplantation genetic testing legislation and accessibility in the Nordic countries [PDF]

, 2020
INTRODUCTION: Assisted reproduction technologies are being rapidly developed and implementation of preimplantation genetic testing (PGT) has allowed patients with genetic disorders to initiate pregnancies while minimizing or eliminating the risk of ...
Hydén-Granskog, Christel, Julius Hreinsson, Snorri Einarsson, Hreinsson, Julius, Hausken, Jon, Jon Hausken, Einarsson, Snorri, Lundin, Kersti, Ingerslev, Hans Jakob, Marie Louise Grøndahl, Iwarsson, Erik, Erik Iwarsson, Hans Jakob Ingerslev, Kersti Lundin, Christel Hydén‐Granskog, Grøndahl, Marie Louise   +15 more
core   +1 more source

Healthy live births after mosaic blastocyst transfers with the use of next-generation sequencing

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: To determine whether transfer of high-mosaicism (≥50%) embryos can result in healthy newborns. Case report: Two embryos resulting from controlled ovarian stimulation (COS) in Patient one, 41 years of age (y/o), underwent preimplantation ...
Yung-Liang Liu, Tzu-Ning Yu, Ching-Hui Chen, Peng-Hui Wang, Chi-Huang Chen, Chii-Ruey Tzeng   +5 more
doaj   +1 more source

Previously reported and here added cases demonstrate euploid pregnancies followed by PGT-A as “mosaic” as well as “aneuploid” designated embryos

Reproductive Biology and Endocrinology, 2023
Background After the longest time opposing all transfers of embryos by preimplantation genetic testing for aneuploidy (PGT-A) diagnosed as “chromosomal-abnormal,” the field has over recent years slowly been moving toward selective transfers of by PGT-A ...
Norbert Gleicher, Pasquale Patrizio, Lyka Mochizuki, David H. Barad   +3 more
doaj   +1 more source

Clinical characteristics of women with preimplantation genetic testing for aneuploidy in freeze all-first (freeze all first and biopsy) versus biopsy-first (biopsy first and freeze normal).

, 2022
Clinical characteristics of women with preimplantation genetic testing for aneuploidy in freeze all-first (freeze all first and biopsy) versus biopsy-first (biopsy first and freeze normal).
Eun-A. Park (13864182), Eun Jeong Yu (8564451), Kyung-Ah Lee (251243), You Shin Kim (8564457), Seung-Ah Choe (5166191)   +4 more
core   +1 more source

The inconsistency between two major aneuploidy-screening platforms—single-nucleotide polymorphism array and next-generation sequencing—in the detection of embryo mosaicism

BMC Genomics, 2022
Background In preimplantation genetic testing for aneuploidy (PGT-A), appropriate evaluation of mosaic embryos is important because of the adverse implications of transferring embryos with high-level mosaicism or discarding those with low-level mosaicism.
Dongjia Chen, Yan Xu, Chenhui Ding, Yali Wang, Yu Fu, Bing Cai, Jing Wang, Rong Li, Jing Guo, Jiafu Pan, Yanhong Zeng, Yiping Zhong, Xiaoting Shen, Canquan Zhou   +13 more
doaj   +1 more source

Cell-free DNA in spent culture medium effectively reflects the chromosomal status of embryos following culturing beyond implantation compared to trophectoderm biopsy.

PLoS ONE, 2021
This prospective study evaluated the accuracy of non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) using cell-free DNA in spent culture medium, as well as that of preimplantation genetic testing for aneuploidy (PGT-A) using ...
Akihiro Shitara, Kazumasa Takahashi, Mayumi Goto, Harunori Takahashi, Takuya Iwasawa, Yohei Onodera, Kenichi Makino, Hiroshi Miura, Hiromitsu Shirasawa, Wataru Sato, Yukiyo Kumazawa, Yukihiro Terada   +11 more
doaj   +1 more source

Evaluation of a novel non-invasive preimplantation genetic screening approach. [PDF]

PLoS ONE, 2018
OBJECTIVE:To assess whether embryonic DNA isolated from blastocyst culture conditioned medium (BCCM) combined with blastocoel fluid (BF) could be used for blastocyst stage non-invasive preimplantation genetic testing for chromosomal aneuploidy (non ...
Valeriy Kuznyetsov, Svetlana Madjunkova, Ran Antes, Rina Abramov, Gelareh Motamedi, Zenon Ibarrientos, Clifford Librach   +6 more
doaj   +1 more source

Preimplantation genetic testing for aneuploidy (PGT-A)—finally revealed

Journal of Assisted Reproduction and Genetics, 2020
Natural fecundity of women decreases gradually and more rapidly after age 37 years. This decrease is accompanied by rising aneuploidy rates of pregnancies and can also be observed in products of conception of spontaneous abortions [1]. These observations lead to the hypothesis that transferring only euploid embryos in association with in vitro ...
Raoul, Orvieto, Norbert, Gleicher
openaire   +3 more sources

Indications for Preimplantation Genetic Testing for Aneuploidy (PGT-A).

, 2018
Indications for Preimplantation Genetic Testing for Aneuploidy (PGT-A).
Rupali Chopra (246435), Barbara Lawrenz (3990386), Human M. Fatemi (3990392), Alberto Liñán (5675405), Ana Arnanz (5675414), Asina Bayram (5675411), Ibrahim El Khatib (5675408), Carmen Rubio (500711)   +7 more
core   +1 more source