Results 61 to 70 of about 85,115,453 (207)

A systematic review and meta-analysis: clinical outcomes of recurrent pregnancy failure resulting from preimplantation genetic testing for aneuploidy

open access: yesFrontiers in Endocrinology, 2023
BackgroundPreimplantation genetic testing for aneuploidy (PGT-A) is an emerging technology that aims to identify euploid embryos for transfer, reducing the risk of embryonic chromosomal abnormalities.
Zhuo Liang   +25 more
doaj   +1 more source

Embryo morphokinetics is potentially associated with clinical outcomes of single embryo transfers in preimplantation genetic testing for aneuploidy cycles

open access: yes, 2019
Time-lapse microscopy was used to compare morphokinetic variables between expanded blastocysts derived from preimplantation genetic testing for aneuploidy cycles using high-resolution next-generation sequencing (hr-NGS).
Lee, C (via Mendeley Data)   +1 more
core   +1 more source

A deep dive into the morphokinetics and ploidy of low-quality blastocysts

open access: yesF&S Reports, 2022
Objective: To describe morphokinetic parameters and ploidy among low-quality blastocysts not meeting the criteria for clinical use. Design: Prospective cohort study. Setting: Academic medical center.
Molly M. Quinn, M.D.   +4 more
doaj   +1 more source

The use of preimplantation genetic testing for aneuploidy (PGT-A): a committee opinion [PDF]

open access: yesFertility and Sterility, 2018
The value of preimplantation genetic testing for aneuploidy (PGT-A) as a screening test for in vitro fertilization (IVF) patients has yet to be determined. Several studies demonstrate higher birth rates after aneuploidy testing and elective single-embryo transfer (eSET), suggesting the potential for this testing to decrease the risk of multiple ...
Alan Penzias   +20 more
openaire   +2 more sources

Association of Intralipid Infusions With Birth Outcomes and First‐Trimester Placental Biomarkers in Frozen Embryo Transfer Cycles: A Retrospective Cohort Study

open access: yesAustralian and New Zealand Journal of Obstetrics and Gynaecology, Volume 66, Issue 5, October 2026.
ABSTRACT Background Intralipid is used as an adjunctive therapy in assisted reproductive technology (ART), but data regarding pregnancy outcomes and early placental biomarkers are limited. Aims To evaluate the association between Intralipid exposure during frozen embryo transfer (FET) cycles and pregnancy outcomes, birthweight and first‐trimester ...
Neerja Kamal   +2 more
wiley   +1 more source

Prenatal exome sequencing of fetuses with central nervous system anomalies based on prenatal ultrasound and magnetic resonance imaging diagnosis: A retrospective cohort study with a systematic review and meta‐analysis

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 1950-1964, October 2026.
Prenatal exome sequencing significantly improves diagnostic yield over chromosomal microarray analysis for fetal CNS abnormalities, with a diagnostic yield of 16% in our cohort and 27% in the meta‐analysis. Diagnostic yields vary across different phenotypes. Abstract Introduction Fetal central nervous system (CNS) abnormalities have diverse etiologies,
Jia Yao   +5 more
wiley   +1 more source

Novel technologies emerging for preimplantation genetic diagnosis and preimplantation genetic testing for aneuploidy

open access: yesExpert Review of Molecular Diagnostics, 2016
Preimplantation genetic diagnosis (PGD) was introduced as an alternative to prenatal diagnosis: embryos cultured in vitro were analysed for a monogenic disease and only disease-free embryos were transferred to the mother, to avoid the termination of pregnancy with an affected foetus.
openaire   +3 more sources

Single‐cell transcriptomic analysis reveals subtle fluctuations of oocyte cryopreservation on mouse early embryo development

open access: yesClinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Mature oocytes were subjected to cryopreservation followed by intracytoplasmic sperm injection (ICSI). Embryos at multiple developmental stages were collected, dissociated into single cells and processed for single‐cell library construction and bioinformatics analysis.
Yixin Ren   +14 more
wiley   +1 more source

DataSheet1_Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression.DOCX

open access: yes, 2023
Aneuploidy in preimplantation embryos is a major cause of human reproductive failure. Unlike uniformly aneuploid embryos, embryos diagnosed as diploid-aneuploid mosaics after preimplantation genetic testing for aneuploidy (PGT-A) can develop into healthy
F. Dominguez (15288205)   +9 more
core   +1 more source

High concordance between next-generation sequencing and single-nucleotide polymorphism array in preimplantation genetic testing for aneuploidy

open access: yesClinical and Experimental Obstetrics & Gynecology, 2022
Background: This study aimed to compare the use of next-generation sequencing (NGS) and single-nucleotide polymorphism (SNP) array in preimplantation genetic testing for aneuploidy (PGT-A) in the same blastocyst.
Zhanhui Ou   +3 more
doaj   +1 more source

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