Results 61 to 70 of about 4,054 (204)

A systematic review and meta-analysis: clinical outcomes of recurrent pregnancy failure resulting from preimplantation genetic testing for aneuploidy

Frontiers in Endocrinology, 2023
BackgroundPreimplantation genetic testing for aneuploidy (PGT-A) is an emerging technology that aims to identify euploid embryos for transfer, reducing the risk of embryonic chromosomal abnormalities.
Zhuo Liang, Zhuo Liang, Zhuo Liang, Zhuo Liang, Zhuo Liang, Zhuo Liang, Qiuyue Wen, Qiuyue Wen, Qiuyue Wen, Qiuyue Wen, Qiuyue Wen, Jingjing Li, Jingjing Li, Jingjing Li, Jingjing Li, Jingjing Li, Dingyuan Zeng, Dingyuan Zeng, Dingyuan Zeng, Dingyuan Zeng, Dingyuan Zeng, Pinxiu Huang, Pinxiu Huang, Pinxiu Huang, Pinxiu Huang, Pinxiu Huang   +25 more
doaj   +1 more source

Facilitating Genetic Testing for Perinatal Demise: Development of a Multidisciplinary Workflow

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1273-1285, June 2026.
ABSTRACT Genetic contributors to perinatal demise are common but frequently undiagnosed due to clinical and logistical barriers. We aimed to improve access to genetic for intrauterine fetal demise (IUFD), stillbirth, and early neonatal death by developing a multidisciplinary workflow.
Mackenzie Mosera, Samantha Stover, Elise Boos, Molly Casey, Joseph Fanning, Chelsea Fechter, Matthew Grace, L. Dupree Hatch, Michaela Ibach, Carla Jackson, Jiancong Liang, Caitlin Mann, Emily A. Morris, Jessica Turnbull, Marie Williams, Bryce A. Schuler   +15 more
wiley   +1 more source

The use of preimplantation genetic testing for aneuploidy (PGT-A): a committee opinion [PDF]

Fertility and Sterility, 2018
The value of preimplantation genetic testing for aneuploidy (PGT-A) as a screening test for in vitro fertilization (IVF) patients has yet to be determined. Several studies demonstrate higher birth rates after aneuploidy testing and elective single-embryo transfer (eSET), suggesting the potential for this testing to decrease the risk of multiple ...
Alan Penzias, Kristin Bendikson, Samantha Butts, Christos Coutifaris, Tommaso Falcone, Gregory Fossum, Susan Gitlin, Clarisa Gracia, Karl Hansen, Andrew La Barbera, Jennifer Mersereau, Randall Odem, Richard Paulson, Samantha Pfeifer, Margareta Pisarska, Robert Rebar, Richard Reindollar, Mitchell Rosen, Jay Sandlow, Michael Vernon, Eric Widra   +20 more
openaire   +2 more sources

Pregnancy Outcomes and Postnatal Health From Transferred Mosaic Embryos Following Preimplantation Genetic Testing for Aneuploidy

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration synthesizes the methods and conclusion of this study, demonstrating that the transfer of mosaic embryos following reimplantation genetic testing for aneuploidy does not increase the risk to postnatal health. ABSTRACT Next‐generation sequencing (NGS) has increased the detection of mosaic embryos during preimplantation genetic testing ...
Lili Chen, Dehuan Huang, Jingcheng Sang, Yiqi Yin, Caiyun Wu, Yan Hao, Dawei Chen, Zhiguo Zhang, Yunxia Cao, Ri‐Cheng Chian, Ping Zhou   +10 more
wiley   +1 more source

High concordance between next-generation sequencing and single-nucleotide polymorphism array in preimplantation genetic testing for aneuploidy

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: This study aimed to compare the use of next-generation sequencing (NGS) and single-nucleotide polymorphism (SNP) array in preimplantation genetic testing for aneuploidy (PGT-A) in the same blastocyst.
Zhanhui Ou, Zhiheng Chen, Yu Deng, Ling Sun   +3 more
doaj   +1 more source

Predicting live birth following single euploid frozen‐embryo transfer via β‐hCG dynamics: iHOPE prognostic model with external validation

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 6, Page 824-835, June 2026.
ABSTRACT Objectives To determine the prognostic value of serum β‐human chorionic gonadotropin (β‐hCG) for predicting live birth following single euploid frozen‐embryo transfer (FET), and to develop and validate a prognostic model (iHOPE) for this purpose. Methods This retrospective cohort study used data from two large fertility practices.
E. Kalafat, B. Ata, R. Del Gallego, A. Freedman, L. R. Hoyos, I. Elkhatib, K. A. Miller, H. Fatemi, B. Lawrenz   +8 more
wiley   +1 more source

Preimplantation Genetic Testing for Aneuploidy Improves Live Birth Rates with In Vitro Produced Bovine Embryos: A Blind Retrospective Study [PDF]

, 2021
Approximately one million in vitro produced (IVP) cattle embryos are transferred worldwide each year as a way to improve the rates of genetic gain. The most advanced programmes also apply genomic selection at the embryonic stage by SNP genotyping and the
Canedo-Ribeiro, Carla, Marras, Gabriele, Giuseppe Silvestri, Labrecque, Remi, Marta Farré, Remi Labrecque, Darren K. Griffin, Steven G. Larmer, Handyside, Alan H., Desmond A.R. Tutt, Tutt, Desmond A.R., Blondin, Patrick, María Serrano-Albal, Alan H. Handyside, Kevin D. Sinclair, Larmer, Steven G., Carla Canedo-Ribeiro, Gabriele Marras, Farré, Marta, Silvestri, Giuseppe, Serrano-Albal, María, Sinclair, Kevin D., Patrick Blondin, Griffin, Darren K.   +23 more
core   +1 more source

Predictive performance of Fetal Medicine Foundation first‐trimester screening algorithm for pre‐eclampsia according to conception mode

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 6, Page 806-814, June 2026.
ABSTRACT Objective To investigate the incidence of pre‐eclampsia (PE) and the predictive performance of the Fetal Medicine Foundation (FMF) first‐trimester PE screening algorithm across pregnancies conceived using assisted reproductive technology (ART), after ovulation induction (OI) and through spontaneous conception (SC).
A. S. L. Kjaer, I. Riishede, L. Rode, R. B. Jensen, K. Pihl, L. Sperling, M. Overgaard, N. G. Pedersen, A. C. Roslev, P. Sandager, A. Tabor, A. Pinborg, C. K. Ekelund, the PRESIDE Study Group, P. Nørgaard, C. Vedel, H. Skov, S. R. Wagner, H. J. Zingenberg, M. R. Andersen, L. Bathum, T. Hilling, C. S. Knudsen, F. S. Jørgensen   +23 more
wiley   +1 more source

DataSheet1_Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression.DOCX

, 2023
Aneuploidy in preimplantation embryos is a major cause of human reproductive failure. Unlike uniformly aneuploid embryos, embryos diagnosed as diploid-aneuploid mosaics after preimplantation genetic testing for aneuploidy (PGT-A) can develop into healthy
F. Dominguez (15288205), A. Quiñonero (15288208), A. Mifsud (3057033), M. Perez (7686263), A. Martin (2484211), A. Delgado (7740095), A. Mercader (15288202), M. J. De Los Santos (15288217), A. Pellicer (15288214), R. Gonzalez-Martin (15288211)   +9 more
core   +1 more source

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, Volume 46, Issue 5-6, Page 623-635, May 2026.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source