Results 51 to 60 of about 3,413 (174)

High concordance between next-generation sequencing and single-nucleotide polymorphism array in preimplantation genetic testing for aneuploidy

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: This study aimed to compare the use of next-generation sequencing (NGS) and single-nucleotide polymorphism (SNP) array in preimplantation genetic testing for aneuploidy (PGT-A) in the same blastocyst.
Zhanhui Ou, Zhiheng Chen, Yu Deng, Ling Sun   +3 more
doaj   +1 more source

We have reached a dead end for preimplantation genetic testing for aneuploidy

Human Reproduction, 2022
Abstract The hypothesis of preimplantation genetic testing for aneuploidy (PGT-A) was first proposed 20 years ago, suggesting that during IVF elimination of aneuploid embryos prior to transfer will improve implantation rates of remaining embryos and, therefore, increase pregnancy and live birth rates, while also reducing miscarriages ...
Norbert Gleicher, David H Barad, Pasquale Patrizio, Raoul Orvieto   +3 more
openaire   +2 more sources

Experiences of Dutch parents undergoing prenatal genomic testing for fetal structural anomalies: A prospective qualitative analysis

Journal of Genetic Counseling, Volume 35, Issue 2, April 2026.
Abstract Prenatal Exome Sequencing (pES) increases the diagnostic rate for genetic disorders in pregnancies with structural abnormalities and substantially impacts parental decision‐making regarding pregnancy continuation or termination. Previous qualitative research on parental experiences of pES has typically been performed several months after ...
Maayke A. de Koning, Sarah Long, Holly E. Evans, Lauren Kelada, Gijs W. E. Santen, Tony Roscioli, Manon Suerink   +6 more
wiley   +1 more source

A Genetic Landscape of Euploid Miscarriages From Couples With Recurrent Pregnancy Loss Through Whole Exome Sequencing

Molecular Genetics &Genomic Medicine, Volume 14, Issue 4, April 2026.
Whole exome sequencing analysis on 55 couples and miscarriages from their current pregnancies reveals a significant heterogeneity and complexity in exomic variants contributing to RPL. ABSTRACT Background This study aimed to identify candidate genes for recurrent pregnancy loss (RPL).
Fanjuan Kong, Zhaochu Yin, Haiyan Zhou, Zhiyu Liu, Wanqin Xie   +4 more
wiley   +1 more source

Does preimplantation genetic testing for aneuploidy improve live birth rate in women diagnosed with recurrent implantation failure: A systematic review and meta‐analysis?

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 4, Page 575-586, April 2026.
Preimplantation genetic testing for aneuploidy may improve both live birth rate per embryo transfer and cumulative live birth rate per cycle for women diagnosed with recurrent implantation failure. Abstract Introduction The prevalence of unexplained recurrent implantation failure (RIF) is reported as 2%–15% in the literature.
Amy Newnham, Charlotte Leeson, Fatima Trunkwala, Joshua Odendaal, Siobhan Quenby   +4 more
wiley   +1 more source

#291 : Association of Maternal Age with Embryonic Aneuploidy and Morphological Score Among Good-Prognosis Infertile Women: A Secondary Analysis of Multicenter, Randomized Controlled Trial

Fertility & Reproduction, 2023
Background and Aims: Maternal age has been reported to impact on embryo genetic status. However, current data on the association between maternal age and early embryo development are limited and inconclusive, especially among good-prognosis women.
Yumei Huang, Wei Zhou, Qian Zhang, Tianxiang Ni, Junhao Yan   +4 more
doaj   +1 more source

Application of microdeletion and microduplication screening in preimplantation genetic testing: a case report

Journal of Medical Case Reports
Background Microdeletions and microduplications are chromosomal variants ranging up to 3 Mb in size. These abnormalities often arise spontaneously and have significant clinical implications, including developmental delay and congenital anomalies.
Maria Katz, Ben Podgursky, Shenglai Li, Qinnan Zhang, Daniel Shapiro, Monica Pasternak, Noor Siddiqui, Funda Suer, Yuntao Xia   +8 more
doaj   +1 more source

Addition of Multi‐Level Technologies to Evaluate Eggs and Embryos and Improve Endometrial Quality Applied for In Vitro Fertilization to Achieve Pregnancy: A Case Study

Clinical Case Reports, Volume 14, Issue 3, March 2026.
This integrated clinical approach optimizes the reproductive cycle in several steps, starting with nutrition (A): restricting carbohydrates and inducing ketosis to reduce inflammation and improve insulin sensitivity, which benefits follicular development.
Tania G. Rojas‐Pérez, Yúvika Reyes‐Albarracín, Ginna Ortiz, Juan José Suárez, Diego Vilchis Reyes, Jacqueline Cordero Oropeza, Dinorah Hernández‐Melchor, Esther López‐Bayghen   +7 more
wiley   +1 more source

Society for Maternal‐Fetal Medicine Consult Series #76: Cancer in pregnancy

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Approximately one in 1000 pregnancies is complicated by the diagnosis of cancer each year, and the incidence of cancer among reproductive‐age individuals is increasing. Management of a pregnant person with cancer can be complex and warrants a multidisciplinary approach to care.
Society for Maternal‐Fetal Medicine (SMFM), Moti Gulersen, Clarissa Bonanno, Justin S. Brandt, Stephanie Pierce, Elyce H. Cardonick, SMFM Publications Committee   +6 more
wiley   +1 more source

Perceptions, motivations and decision regret surrounding preimplantation genetic testing for aneuploidy

Human Reproduction, 2020
Abstract STUDY QUESTION Is there a difference in level of decision regret following IVF treatment between those who choose to complete or not complete preimplantation genetic testing for aneuploidy [PGT-A]?
Amy, Kaing, Mitchell P, Rosen, Molly M, Quinn   +2 more
openaire   +2 more sources