Changes in sequencing technology used for preimplantation genetic testing for aneuploidy [PDF]
Journal of Assisted Reproduction and GeneticsAbstract The continued development of assisted reproductive technologies has aimed to improve pregnancy outcomes through screening methods for the identification of embryos with monogenic disorders, chromosomal aneuploidy or structural abnormalities.
Vivianne Elizabeth Oltramare +2 more
core +4 more sources
Preimplantation Genetic Testing for Aneuploidy – a Castle Built on Sand [PDF]
Trends in Molecular Medicine, 2021 Preimplantation genetic testing for aneuploidy (PGT-A) has become a routine add-on for in vitro fertilization (IVF) to determine whether human embryos are to be clinically utilized or disposed of. Studies claiming IVF outcome improvements following PGT-A, however, used highly selected patient populations or inappropriate statistical methodologies.
Norbert, Gleicher +2 more
openaire +3 more sources
Spectrum of Various Mosaicism Types According to Female Age: An Analysis of 36,506 Blastocysts Using Preimplantation Genetic Testing for Aneuploidy [PDF]
BiomedicinesBackground/Objectives: Mosaicism in preimplantation embryos has important implications for embryo selection and reproductive outcomes. This study investigates the age-related frequency of mosaicism, analyzes its subtypes, and evaluates its clinical ...
Kyung Ah Lee +9 more
core +2 more sources
Does preimplantation genetic testing for aneuploidy improve live birth rate in women diagnosed with recurrent implantation failure: A systematic review and meta‐analysis? [PDF]
Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 4, Page 575-586, April 2026.Preimplantation genetic testing for aneuploidy may improve both live birth rate per embryo transfer and cumulative live birth rate per cycle for women diagnosed with recurrent implantation failure. Abstract Introduction The prevalence of unexplained recurrent implantation failure (RIF) is reported as 2%–15% in the literature.
Amy Newnham +4 more
wiley +2 more sources
Next generation sequencing for preimplantation genetic testing of blastocysts aneuploidies in women of different ages [PDF]
Annals of Agricultural and Environmental Medicine, 2015 Most of the current preimplantation genetic screening of aneuploidies tests are based on the low quality and low density comparative genomic hybridization arrays. The results are based on fewer than 2,700 probes.
Krzysztof Lukaszuk +7 more
doaj +2 more sources
Taiwanese Journal of Obstetrics & Gynecology, 2019 Objective: The primary objective of this study was to investigate whether preimplantation genetic testing for aneuploidy (PGT-A) of blastocysts through array comparative genomic hybridization (aCGH) improves live birth rates (LBR) in IVF cycles for ...
Chun-I. Lee +6 more
doaj +2 more sources
A systematic review and meta-analysis of the diagnostic accuracy after preimplantation genetic testing for aneuploidy [PDF]
PLoS OneOBJECTIVE: Aneuploidy accounts for many pregnancy failures and congenital anomalies. Preimplantation genetic testing for aneuploidy (PGT-A) is a screening test applied to embryos created from in vitro fertilization to diminish the chance of an aneuploid ...
Bacal, Vanessa +8 more
core +2 more sources
The Application of Clinical GeneticsYang Liu,1– 6,* Xiangxin Lan,1– 6,* Juanjuan Lu,1– 6,* Qian Zhang,1– 6 Tingting Zhou,1– 6 Tianxiang Ni,1– 6 Junhao Yan1– 6 1Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Key ...
Liu Y +6 more
doaj +1 more source
Conventional in vitro fertilization enhances preimplantation genetic testing for aneuploidy outcomes in couples with non-male factor infertility [PDF]
Scientific ReportsWhile extensive research has compared ICSI and c-IVF in general ART outcomes, limited evidence exists regarding their relative efficacy and safety in PGT-A cycles.
Xiaolan Li +6 more
doaj +2 more sources
Reproductive MedicinePreimplantation genetic testing for aneuploidy (PGT-A) has become a useful approach for embryo selection following IVF and ICSI. However, the biopsy process associated with PGT-A is expensive, prone to errors in embryo ploidy determination, and ...
Katharine R. B. Phillips +8 more
doaj +2 more sources