Results 51 to 60 of about 225,831 (315)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Developmental potential of oocytes fertilized by conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) after cryopreservation and mesometrial autotransplantation of rabbit ovarian tissue

Animal, 2008
Objective: To evaluate mesometrial transplantation of frozen-thawed ovarian tissue in rabbit and to choose the optimized fertilization method for oocytes retrieved from grafts by investigating the capability of oocyte fertilization and further ...
C. Lan, D. Xiaohui, F. Qingzhao, X. Anran, H. Chun-yan, Y. Hongling, Y. Xuan   +6 more
doaj   +1 more source

Blastocyst Morphology Based on Uniform Time-Point Assessments is Correlated With Mosaic Levels in Embryos

Frontiers in Genetics, 2021
Avoiding aneuploid embryo transfers has been shown to improve pregnancy outcomes in patients with implantation failure and pregnancy loss. This retrospective cohort study aims to analyze the correlation of time-lapse (TL)-based variables and numeric ...
Chien-Hong Chen, Chun-I Lee, Chun-I Lee, Chun-I Lee, Chun-Chia Huang, Hsiu-Hui Chen, Shu-Ting Ho, En-Hui Cheng, Pin‐Yao Lin, Chung-I Chen, Tsung-Hsien Lee, Tsung-Hsien Lee, Tsung-Hsien Lee, Maw-Sheng Lee, Maw-Sheng Lee, Maw-Sheng Lee   +15 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Successful Outcome Following Hysteroscopic Septoplasty in a Woman with Seven Consecutive Pregnancy Losses

Fertility & Reproduction, 2021
Anomalies of the reproductive tract are common and present in about 3%–5% of the general population and in about 3% of infertile women. In general, they are asymptomatic, but they can also be associated with recurrent abortions or infertility.
Jesmine Banu, Mumtahena Amir, Shakeela Ishrat, Sadia Afrin Munmun, Nighat Sultana   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

“It’s a big deal, being given a person” – a study of the links between infertility and adoption [PDF]

, 2015
This study was commissioned and funded by Family Care and undertaken by Jo Ward and Joe Smeeton, both Principal Lecturers at Nottingham Trent University.
Smeeton, J., Ward, J, Ward, J., Smeeton, J   +3 more
core  

Improved clinical outcomes with a modified warming protocol in donor oocyte cycles

Journal of Ovarian Research
Background Recent studies have attempted to improve laboratory efficiency while preserving clinical outcomes by shortening the time to warm cryopreserved embryos, though it is still unclear for oocytes.
Chun-I Lee, Hsiu-Hui Chen, Shu-Hui Lin, Chun-Chia Huang, Pin-Yao Lin, Tsung-Hsien Lee, Ming-Jer Chen, Maw-Sheng Lee, Chien-Hong Chen   +8 more
doaj   +1 more source

Transvaginal sonography and surgical findings in the diagnosis of endometriosis individuals: A cross-sectional study

International Journal of Reproductive BioMedicine, 2023
Background: Endometriosis is a challenging gynecological disease and a debilitating condition that profoundly affects the individual's quality of life.
Roya Padmehr, Khadijeh Shadjoo, Arash Mohazzab, Atefeh Gorgin, Roxana Karegar, Parvin Jaberipour, Zahra Sehat, Narges Maleki   +7 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source