Results 51 to 60 of about 259,314 (253)

Comparison of Day 14 Serum Progesterone Level Based on Pregnancy Outcome in Patients Undergoing Intracytoplasmic Sperm Injection Cycles [PDF]

Journal of Kerman University of Medical Sciences, 2015
Background & Aims: Serum progesterone level (as early as 4 weeks gestation) reflects the relation between embryo and corpus luteum. The purpose of the present study was to compare serum progesterone level on day 14 after embryo transfer among 3 groups of
Marzieh Mehrafza, Azadeh Raouf, Talieh Rahimian, Zahra Nikpouri, Parvaneh Abdollahian, Ahmad Hosseini   +5 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Evaluation of the Osteogenic Potential of Apigenin via Inducing Autophagy: An In Vitro Study

Stem Cells International
The present study aimed to evaluate the effect of apigenin (Api) on the osteogenic differentiation of adipose tissue-derived mesenchymal stem cells (ASCs) by stimulating autophagy.
Mozafar Khazaei, Amirmohammad Khodaei, Maryam Bozorgi, Mohammad Rasool Khazaei, Azam Bozorgi   +4 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The First Report of Successfully Pregnancy after ICSI with Combined DGC/Zeta Sperm Selection Procedure in a Couple with Eleven Repeated Fail IVF/ICSI Cycles [PDF]

International Journal of Fertility and Sterility, 2010
This is the first report implementing combined density gradient centrifugation/Zeta (DGC/Zeta) sperm selection procedure for a couple with eleven previous intra cytoplasmic sperm injection/ in vitro fertilization (ICSI/IVF) failure cycles. Semen analysis
Mohammad Reza Deemeh, Marziyeh Tavalaee, Seyed Mahdi Ahmadi, Seyed Asadolah Kalantari, Seyed Vali Alavi Nasab, Mohammad Hassan Najafi, Mohammad Hossein Nasr Esfahani   +6 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Future Perspectives in the Diagnosis and Management of Unexplained Male Infertility

, 2015
Unexplained male infertility (UMI) remains a challenge to both the physician and the patient. Currently, the management options for unexplained infertility, beyond assisted reproductive techniques, are typically limited to empiric therapies. This chapter
Peter N. Schlegel, Schlegel, Peter N, Avinash Maganty, Ramasamy, Ranjith, Ranjith Ramasamy, Maganty, Avinash   +5 more
core   +1 more source

Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice

Middle East Fertility Society Journal
Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles.
Anastasia A. Salame, Elias M. Dahdouh, Rania Aljafari, David A. Samuel, Bhavya P. Koodathingal, Aparna Bajpai, Shabin Kainoth, Michael Fakih   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Investigating Marital Relationship in Infertility: A Systematic Review of Quantitative Studies [PDF]

, 2012
Background: Infertility is a complex issue that affects individuals and groups, and also it has serious implications for the mental and social well-being of those involved.
Coates, Rosemary, Tao, Peng, Maycock, Bruce   +2 more
core