Results 51 to 60 of about 224,723 (313)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Infertility and its management from a pharmacological perspective
, 2023 Infertility is defined as the inability to conceive after at least 12 months of regular and unprotected sexual intercourse. Infertility is a medical problem of increasing prevalence and is estimated to affect 8-12% of couples of reproductive age ...
Dagsson, Gunnar Þór
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Embryos With “No Result” After PGT-A: A Retrospective Analysis of Causative Factors
Obstetrics and Gynecology InternationalConclusion: No clear embryo-related risk factors could be elucidated; however, the biopsy procedure and sample cellularity seem to be crucial components.
Anastasia Salame +8 more
doaj +1 more source
Religion, Infertility and Infertility Treatment [PDF]
, 2013 Infertility is a common medical condition. An estimated 9% of women between the ages of 20 and 44 experience infertility, which equates to over 70 million women worldwide. However, infertility is more than a medical condition.
Hudson, Nicky +3 more
core
The social infertility cycle model
, 2023 Infertility poses an immense challenge to contemporary society. Around one in six people worldwide trying to conceive a child are facing infertility. This situation exists in an age of great technological developments where advances in medicine have made
Alicja Malina
core +1 more source
American family physician, 2007 Infertility is defined as failure to achieve pregnancy during one year of frequent, unprotected intercourse. Evaluation generally begins after 12 months, but it can be initiated earlier if infertility is suspected based on history or if the female partner is older than 35 years.
Jose-Miller, A B, Boyden, J W, Frey, K A
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Evaluation of the Osteogenic Potential of Apigenin via Inducing Autophagy: An In Vitro Study
Stem Cells InternationalThe present study aimed to evaluate the effect of apigenin (Api) on the osteogenic differentiation of adipose tissue-derived mesenchymal stem cells (ASCs) by stimulating autophagy.
Mozafar Khazaei +4 more
doaj +1 more source