Results 51 to 60 of about 361,626 (308)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
International Journal of Reproductive BioMedicine, 2023 Background: Endometriosis is a challenging gynecological disease and a debilitating condition that profoundly affects the individual's quality of life.
Roya Padmehr +7 more
doaj +1 more source
Fertility & Reproduction, 2021 Anomalies of the reproductive tract are common and present in about 3%–5% of the general population and in about 3% of infertile women. In general, they are asymptomatic, but they can also be associated with recurrent abortions or infertility.
Jesmine Banu +4 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Effects of Cabergoline Compared to Dienogest in Women with Symptomatic Endometrioma
Fertility & Reproduction, 2021 Background: New vessel formation or neovascularization has been recognized as a feature of endometriosis. Treatment with cabergoline suppresses cell proliferation and vascular-endothelial-growth-factor-mediated angiogenesis, thereby promoting regression ...
Mehnaz Mustary Shume +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Improved clinical outcomes with a modified warming protocol in donor oocyte cycles
Journal of Ovarian ResearchBackground Recent studies have attempted to improve laboratory efficiency while preserving clinical outcomes by shortening the time to warm cryopreserved embryos, though it is still unclear for oocytes.
Chun-I Lee +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Use of a Hysteroscopic Tissue Removal System for Revision of Cesarean Scar Isthmocele: A Case Report
Case Reports in Obstetrics and GynecologyCesarean scar isthmocele (CSI) is a defect in the anterior myometrial wall of the uterine isthmus, at the site of a previous cesarean scar, and can be associated with menorrhagia in the form of prolonged menstrual bleeding or spotting, dysmenorrhea, and ...
Shahryar K. Kavoussi +5 more
doaj +1 more source
American family physician, 2007 Infertility is defined as failure to achieve pregnancy during one year of frequent, unprotected intercourse. Evaluation generally begins after 12 months, but it can be initiated earlier if infertility is suspected based on history or if the female partner is older than 35 years.
Jose-Miller, A B, Boyden, J W, Frey, K A
openaire +2 more sources