Results 91 to 100 of about 382,145 (280)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Embeddings of infinite graphs

open access: yesJournal of Combinatorial Theory, Series B, 1988
Embeddings of infinite graphs in surfaces (not necessarily compact) without boundary are considered. Cellular embeddings are studied in details. Each rotation system of a locally finite graph G gives rise to a cellular embedding of G into some surface, and every cellular embedding with all 2-cells of finite size can be obtained in this way.
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Fragments and Automorphisms of Infinite Graphs

open access: yesEuropean Journal of Combinatorics, 1984
The authors investigate the structure of infinite graphs \(\Gamma\) with \(\kappa_{\infty}(\Gamma)
Heinz Adolf Jung, Mark E. Watkins
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

A Note on Pseudofinite Acyclic Graphs

open access: yesИзвестия Иркутского государственного университета: Серия "Математика"
Acyclic graphs approximated by finite acyclic graphs are considered. It is proved that any countably categorical acyclic graph is smoothly approximable. An example of pseudofinite acyclic graph theory is given, which has an even, odd, and infinite number
N. D. Markhabatov, Ye. R. Baissalov
doaj   +1 more source

Infinite graphs—A survey

open access: yesJournal of Combinatorial Theory, 1967
AbstractThis expository article describes work which has been done on various problems involving infinite graphs, mentioning also a few unsolved problems or suggestions for future investigation.
openaire   +2 more sources

Decomposing infinite graphs

open access: yesDiscrete Mathematics, 1991
The author gives an introductory survey of the theory of simplicial and related decompositions of graphs. It is based mainly on his recent book ``Graph decompositions. A study in infinite graph theory'' (1990; Zbl 0726.05001). Several open problems are presented.
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Matroid and Tutte-connectivity in infinite graphs [PDF]

open access: yes, 2012
We relate matroid connectivity to Tutte-connectivity in an infinite graph. Moreover, we show that the two cycle matroids, the finite-cycle matroid and the cycle matroid, in which also infinite cycles are taken into account, have the same connectivity ...
Bruhn, Henning
core  

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