Results 101 to 110 of about 382,145 (280)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Trace formulae for graph Laplacians with applications to recovering matching conditions [PDF]
, 2014 Graph Laplacians on finite compact metric graphs are considered under the assumption that the matching conditions at the graph vertices are of either $\delta$ or $\delta'$ type. In either case, an infinite series of trace formulae which link together two
Alexander, V. Kiselev, Yulia Ershova
core
The incidence chromatic number of some graph
International Journal of Mathematics and Mathematical Sciences, 2005 The concept of the incidence chromatic number of a graph was introduced by Brualdi and Massey (1993). They conjectured that every graph G can be incidence colored with Δ(G)+2 colors.
Liu Xikui, Li Yan
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2020 We have observations concerning the set theoretic strength of the following combinatorial statements without the axiom of choice. 1. If in a partially ordered set, all chains are finite and all antichains are countable, then the set is countable. 2.
Banerjee, Amitayu, Gyenis, Zalán
core
3-Chloro-4-hydroxyfuran-2(5H)-one
Acta Crystallographica Section E, 2009 In the title compound, C4H3ClO3, molecules are linked via O—H...O hydrogen bonds into an infinite chain with graph-set motif C(6) along the c axis.
Na Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Mathematics OpenThe cycle graph of a graph G is the graph [Formula: see text] whose vertices are the induced cycles of G and where two vertices are adjacent if and only if they are distinct induced cycles that share a common edge.
Severino V. Gervacio, Yvette F. Lim
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source