Results 11 to 20 of about 74,643 (165)

Cytokine transcriptome profiling in acute experimental canine atopic dermatitis skin lesions after IL‐31 inhibition with lokivetmab

Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023
Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki, Natalie Crawford, Jordan M. Eder, Andrea J. Gonzales, Thierry Olivry   +4 more
wiley   +1 more source

Concentrations of neutrophil gelatinase‐associated lipocalin are increased in serum and peritoneal fluid from horses with inflammatory abdominal disease and non‐strangulating intestinal infarctions

Equine Veterinary Journal, Volume 55, Issue 3, Page 426-434, May 2023., 2023
Abstract Background Neutrophil gelatinase‐associated lipocalin (NGAL) is produced in response to inflammation in horses, but it has not yet been investigated as a biomarker in horses with the abdominal disease. Objectives To investigate NGAL in serum and peritoneal fluid in horses with the abdominal disease.
Malou F. Winther, Simon L. Haugaard, Tina H. Pihl, Stine Jacobsen   +3 more
wiley   +1 more source

High mobility group box 1, ATP, lipid mediators, and tissue factor are elevated in COVID‐19 patients: HMGB1 as a biomarker of worst prognosis

Clinical and Translational Science, Volume 16, Issue 4, Page 631-646, April 2023., 2023
Abstract The severe acute respiratory syndrome coronavirus 2, the agent of the ongoing coronavirus disease 2019 (COVID‐19) pandemic, has spread worldwide since it was first identified in November 2019 in Wuhan, China. Since then, progress in pathogenesis linked severity of this systemic disease to the hyperactivation of network of cytokine‐driven pro ...
Amanda Roberta Revoredo Vicentino, Vanderlei da Silva Fraga‐Junior, Matheus Palazzo, Natalia Recardo Amorim Tasmo, Danielle A. S. Rodrigues, Shana Priscila Coutinho Barroso, Sâmila Natiane Ferreira, Anna Cristina Neves‐Borges, Diego Allonso, Marcelo Rosado Fantappié, Julio Scharfstein, Ana Carolina Oliveira, Rosane Vianna‐Jorge, André Macedo Vale, Robson Coutinho‐Silva, Luiz Eduardo Baggio Savio, Claudio Canetti, Claudia Farias Benjamim   +17 more
wiley   +1 more source

Similar Inflammatory Adaptation in Women following 10 Weeks of Two Equalized Resistance Training with Different Muscle Action Duration

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
This study is aimed at evaluating the profile of inflammatory markers and components of redox regulation in untrained women after 10 weeks of resistance training using equalized protocols but different muscle action duration (MAD). Twenty‐two women underwent progressive resistance training exercising the knee extensor muscles for 10 weeks—3x/week, with
Kelerson Mauro de Castro Pinto, Rodrigo César Ribeiro Diniz, Frank Douglas Tourino, Lucas Túlio de Lacerda, Eduardo Bearzoti, Karine Beatriz Costa, Débora Maria Soares de Souza, Fernando Vitor Lima, Etel Rocha-Vieira, Mauro Heleno Chagas, Andre Talvani, Chuan Ye   +11 more
wiley   +1 more source

Onset and duration of action of lokivetmab in a canine model of IL‐31 induced pruritus

Veterinary Dermatology, Volume 32, Issue 6, Page 681-e182, December 2021., 2021
Onset of antipruritic action of lokivetmab in dogs. Laboratory‐bred beagle dogs were dosed subcutaneously with either placebo or lokivetmab at 2.0 mg/kg on Day (D) 0. Approximately 2.5 h post‐dosing, pruritus was induced using canine interleukin (IL)‐31. Animals were observed for pruritic behaviours for a total of 2 h (3–5 h post‐treatment with placebo
Timothy J. Fleck, Lori R. Norris, Sean Mahabir, Rodney R. Walters, Olivier Martinon, Steven A. Dunham, Andrea J. Gonzales   +6 more
wiley   +1 more source

Cutaneous microRNA expression in healthy Labrador and Golden retrievers and retrievers with allergic and inflammatory skin diseases

Veterinary Dermatology, Volume 32, Issue 4, Page 331-e92, August 2021., 2021
Background MicroRNAs (miRNA) are short, single‐stranded RNA molecules that regulate gene expression in a post‐transcriptional manner. Their expression is proposed to be tissue‐specific and alterations in miRNA expression have been detected in many diseases. Objective To compare miRNA expression in the skin of healthy Labrador and golden retrievers, and
Marie Isabel Morlang, Karin Weber, Wolf von Bomhard, Ralf S. Mueller   +3 more
wiley   +1 more source

Immunopathogenesis of the feline atopic syndrome

Veterinary Dermatology, Volume 32, Issue 1, Page 13-e4, February 2021., 2021
Résumé Contexte Les maladies félines supposées d’origine allergique avec des phénotypes cliniques semblables, peuvent avoir de nombreuses pathogénies différentes sous jacentes. Le phénotype clinque, l’étiologie précise et l’immunopathogénie sous jacente doivent tous être considérés si des avancées veulent être faites dans ces domaines négligés de la ...
Richard Halliwell, Frane Banovic, Ralf S. Mueller, Thierry Olivry   +3 more
wiley   +1 more source

Aerobic Training Modulates the Increase in Plasma Concentrations of Cytokines in response to a Session of Exercise

Journal of Environmental and Public Health, Volume 2021, Issue 1, 2021., 2021
Acute physical exercise can modulate immune function. For example, acute exercise is known to increase the circulating concentration of cytokines. Exercise is also known to modulate immune function chronically. It is not known whether exercise training can result in training of the immune system.
Tatiana Ramos Fonseca, Thiago Teixeira Mendes, Guilherme Passos Ramos, Christian Emmanuel Torres Cabido, Rodrigo Figueiredo Morandi, Fernanda Oliveira Ferraz, Aline Silva Miranda, Vanessa Amaral Mendonça, Antônio Lúcio Teixeira, Emerson Silami-Garcia, Albená Nunes-Silva, Mauro Martins Teixeira, Amir Radfar   +12 more
wiley   +1 more source

Oxidative Imbalance as a Crucial Factor in Inflammatory Lung Diseases: Could Antioxidant Treatment Constitute a New Therapeutic Strategy?

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Inflammatory lung disease results in a high global burden of death and disability. There are no effective treatments for the most severe forms of many inflammatory lung diseases, such as chronic obstructive pulmonary disease, emphysema, corticosteroid‐resistant asthma, and coronavirus disease 2019; hence, new treatment options are required.
Tatiana Victoni, Emiliano Barreto, Vincent Lagente, Vinicius F. Carvalho, Jayeeta Ghose   +4 more
wiley   +1 more source

The Role of Oxidative Imbalance on Pulmonary Diseases

, 2022
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022.
Vinicius Frias Carvalho, Emiliano Barreto, Tatiana Victoni, Vincent Lagente   +3 more
wiley   +1 more source