Results 1 to 10 of about 1,151 (128)
Estresse oxidativo e diminuição de HSP70 tecidual envolvidos na gênese da sepse: HSP70 como alvo terapêutico [PDF]
Revista Brasileira de Terapia Intensiva, 2020 RESUMO A sepse é uma infecção sistêmica que acarreta disfunção múltipla dos órgãos. A HSP70 é uma proteína responsiva ao estresse celular, assim como o estresse oxidativo. Esta revisão da literatura buscou investigar a HSP70 e o estresse oxidativo quanto
Maicon Machado Sulzbacher +2 more
doaj +4 more sources
Frontiers in Physiology, 2021 Complications generated by hyperglycemia present in diabetes mellitus (DM) have been constantly related to oxidative stress and dysfunction in the mitochondrial electron transport chain (ETC).
Caroline Calloni +5 more
doaj +1 more source
Brain, Behavior, & Immunity - Health, 2021 HSP70 is one of the main molecular chaperones involved in the cellular stress response. Besides its chaperone action, HSP70 also modulates the immune response.
Camila Tiefensee Ribeiro +14 more
doaj +1 more source
Tetrahydrobiopterin: Beyond Its Traditional Role as a Cofactor
Antioxidants, 2023 Tetrahydrobiopterin (BH4) is an endogenous cofactor for some enzymatic conversions of essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the metabolism of phenylalanine and lipid esters.
Tuany Eichwald +10 more
doaj +1 more source
Characterization and modulation of microglial phenotypes in an animal model of severe sepsis
Journal of Cellular and Molecular Medicine, Volume 24, Issue 1, Page 88-97, January 2020., 2020 Abstract We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammation in an animal model of severe sepsis and the effects of minocycline on these phenotypes. Rats were subjected to CLP, and some animals were treated with minocycline (10 ug/kg) by i.c.v. administration.
Monique Michels +11 more
wiley +1 more source
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2020, Issue 1, 2020., 2020 Context. Chaptalia nutans (L.) Pol. (family: Asteraceae) is widely used in traditional medicine as laxative and anticough medications and especially in the traumatisms, wounds, and hemorrhages in topical preparations. Objective. This work was to evaluate the chemical constitution of the hydromethanolic (30/70 methanol‐water) macerating extract obtained
Letiele Bruck de Souza +9 more
wiley +1 more source
Coagulation biomarkers and coronavirus disease 2019 phenotyping: a prospective cohort study
Thrombosis Journal, 2023 Background Because severe acute respiratory syndrome coronarivus 2 (SARS-CoV-2) leads to severe conditions and thrombus formation, evaluation of the coagulation markers is important in determining the prognosis and phenotyping of patients with COVID-19 ...
Emily Corneo +11 more
doaj +1 more source
Data in Brief, 2016 Jaboticaba (Plinia trunciflora (O. Berg) Kausel) is a Brazilian native berry, which presents high levels of polyphenols. Here we provide data related to the effects of the polyphenols-rich extract from jaboticaba on the cell viability, mitochondrial ...
Caroline Calloni +3 more
doaj +1 more source
Scientific Reports, 2017 The receptor for advanced glycation endproducts (RAGE) is a pattern-recognition receptor associated with inflammation in most cell types. RAGE up-regulates the expression of proinflammatory mediators and its own expression via activation of NF-kB. Recent
Juciano Gasparotto +9 more
doaj +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019 Objective. In this study, we evaluated the efficacy of simvastatin in the treatment of nonalcoholic steatohepatitis induced by methionine and choline‐deficient diet in mice and its possible effect on factors involved in the pathogenesis of the disease including oxidative stress and endoplasmic reticulum stress. Method.
Graziella Rodrigues +10 more
wiley +1 more source