Results 161 to 170 of about 47,495 (266)

Evaluation of ASC as a therapeutic target for Alzheimer's disease. [PDF]

Alzheimers Dement
Clayton WB, Kulas JA, Liu J, Walia N, Rangel-Barajas C, Johnson T, Zhang J, Huang K, Mesecar AD, Dage JL, Lamb BT, Palkowitz AD, Richardson TI.   +12 more
europepmc   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Nano‐networks via reaction‐induced self‐assembly coordinate spatiotemporal multi‐drug delivery for acute kidney injury therapy

BMEMat, EarlyView.
Multifunctional nano‐networks (NNWs) are prepared via reaction‐induced self‐assembly (RISA) of spermidine (SPD), epigallocatechin gallate (EGCG), 2‐formylphenylboronic acid (2‐FPBA), and deferoxamine (DFO) through dynamic iminoboronate bonds. These NNWs leverage the oxidative AKI microenvironment to trigger disintegration, enabling site‐specific ...
Juan Jin, Xiao Zhang, Chenxi Wang, Taian Jin, Xinyang Fang, Yixuan Gao, Mengchun Chen, Weiyang Meng, Chang Gao, Wenlu Li, Yuanfeng Li, Yijie Chen, Calvin A. Omolo, Thirumala Govender, Linqi Shi, Yunguang Wang, Yong Liu, Qiang He   +17 more
wiley   +1 more source

IL-1 signaling and inflammasomes in acute myeloid leukemia: mechanisms and therapeutic opportunities. [PDF]

Cell Mol Life Sci
Mortellaro A, Mastaglio S, Muzio M.
europepmc   +1 more source

Multiscale simulation unravel the kinetic mechanisms of inflammasome assembly

, 2019
Zhaoqian Su, Yinghao Wu
openalex   +2 more sources

Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214‐9, on Mitochondrial Fragmentation and Lytic Cell Death

Cytoskeleton, EarlyView.
ABSTRACT Septins are conserved GTP‐binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenuron (FCF) was the first small molecule identified to modify septins, disrupting their organisation and ...
Dominik Brokatzky, Rajdeep Das, Hannah Painter, Rakesh K. Singh, Serge Mostowy   +4 more
wiley   +1 more source

Linking AIM2 Inflammasome Activation, Mitochondrial Dysfunction and Chronic Inflammation in Ankylosing Spondylitis. [PDF]

Cells
Boengiu CA, Barbulescu AL, Dragomirescu CC, Buga AM, Mirea AA.   +4 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

The Role of Inflammasomes in LPS and Gram-Negative Bacterial Sepsis. [PDF]

J Clin Med
Hernández-Cuellar E, Tsuchiya K, Medina-Contreras O, Valle-Ríos R.   +3 more
europepmc   +1 more source

Differential Peripheral NLRP3 Inflammasome Expression in Parkinson's Disease and Multiple System Atrophy [PDF]

Jeffrey Lee, Han‐Joon Kim, Hữu Đạt Nguyễn, Suk Jun Song, T. Nguyen Thanh, In Hee Kwak, HK Choi, Hyeo‐Il Ma, Young‐Eun Kim   +8 more
openalex   +1 more source