Results 261 to 270 of about 90,432 (374)

Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome

, 2009
Julie Delaloye, Thierry Roger, Quynh-Giao Steiner-Tardivel, Didier Le Roy, Marlies Knaup Reymond, Shizuo Akira, Virginie Pétrilli, Carmen Gómez, Beatriz Perdiguero, Jürg Tschopp, Giuseppe Pantaleo, Mariano Estéban, Thierry Calandra   +12 more
openalex   +2 more sources

Activation of the NLRP3 inflammasome by intracellular poly I:C [PDF]

, 2010
Jayant V. Rajan, Sarah Warren, Edward A. Miao, Alan Aderem   +3 more
openalex   +1 more source

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis

Cancer Communications, EarlyView.
Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan, Jinsong Xu, Zhanqiao Zhang, Yating Hu, Yongsheng Li, Junying Qian, Yunyan Ling, Dehua Wu, Haijun Deng, Guoxin Li, Zhiyong Shen, Yuan Fang   +11 more
wiley   +1 more source

The role of pyroptosis in ovarian cancer. [PDF]

Discov Oncol
Zhou Y, Peng T, Zhang J, Liang R.
europepmc   +1 more source

Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion [PDF]

, 2010
Takahiro Shimada, Bong Goo Park, Andrea J. Wolf, Constantinos Brikos, Helen S. Goodridge, Courtney Becker, Christopher N. Reyes, Edward A. Miao, Alan Aderem, Friedrich Götz, George Y. Liu, David M. Underhill   +11 more
openalex   +1 more source

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, EarlyView.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source

Roles of Inflammasomes in Inflammatory Responses and Human Diseases. [PDF]

Int J Mol Sci
Yi YS.
europepmc   +1 more source

Inflammasome-dependent Caspase-1 Activation in Cervical Epithelial Cells Stimulates Growth of the Intracellular Pathogen Chlamydia trachomatis

, 2009
Ali A. Abdul‐Sater, Evonne Koo, Georg Häcker, David M. Ojcius   +3 more
openalex   +1 more source

Inflammasomes as mediators of immunity against influenza virus [PDF]

, 2010
Iris K. Pang, Akiko Iwasaki
openalex   +1 more source

Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, EarlyView.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source