Results 171 to 180 of about 2,403,937 (295)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

RETRACTION: A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation

Mediators of Inflammation
Mediators of Inflammation
doaj   +1 more source

Reconceptualizing Peri-Implantitis: Dual-Factor Inflammation and Its Role in Advancing Biomaterial Coatings. [PDF]

Clin Implant Dent Relat Res
Cunha DM, Santana AP, Guerreiro MM, Chaurasia A, Sculean A, de Molon RS, de Avila ED.   +6 more
europepmc   +1 more source

Gallic acid ameliorates synovial inflammation and fibrosis by regulating the intestinal flora and its metabolites

Junfeng Kang, Lishi Jie, Guozhen Lu, Houyu Fu, Taiyang Liao, Deren Liu, Lei Shi, Songjiang Yin, Li Zhang, Peimin Wang   +9 more
openalex   +1 more source

Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes

, 2018
Yaozhen Chen, Xiangyang Qin, Qunxing An, Jing Yi, Fan Feng, Dandan Yin, Ning An, Zheng Liu, Lihong Weng, Shouwen Chen, Xingbin Hu, Wen Yin   +11 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

ATG9A-dependent, LC3-independent autophagy curbs the immune system to protect against disease. [PDF]

Autophagy Rep
Priem D, Bertrand MJ.
europepmc   +1 more source

Choroidal Thickness Indicates Subclinical Ocular and Systemic Inflammation in Eyes with Behçet Disease without Active Inflammation

, 2018
Yoo-Ri Chung, Eun Hyung Cho, Se-Ran Jang, Seung Yeop Lee, Eun‐So Lee, Kihwang Lee   +5 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

The Ketogenic Diet: An Anti-Inflammatory Treatment for Schizophrenia?

Journal of Inflammation Research
Alexis A Hung,1 James R Krycer,1 Zoltan Sarnyai,2 Christopher M Palmer,3 Severine Navarro1 1Infection and Inflammation Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; 2Margaret Roderick Centre for Mental Health Research ...
Hung AA, Krycer JR, Sarnyai Z, Palmer CM, Navarro S   +4 more
doaj