Systemic inflammation predicts all-cause mortality: a Glasgow Inflammation Outcome Study [PDF]
, 2015 Introduction: Markers of the systemic inflammatory response, including C-reactive protein and albumin (combined to form the modified Glasgow Prognostic Score), as well as neutrophil, lymphocyte and platelet counts have been shown to be prognostic of ...
Fletcher, Colin D. +5 more
core +10 more sources
The trinity of COVID-19: immunity, inflammation and intervention
Nature reviews. Immunology, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and ...
M. Tay +4 more
semanticscholar +1 more source
Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
Nature reviews. Immunology, 2020 The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in ...
M. Merad, Jérôme C. Martin
semanticscholar +1 more source
Inflammation and aging: signaling pathways and intervention therapies
Signal Transduction and Targeted Therapy, 2023 Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases.
Xia Li +5 more
semanticscholar +1 more source
Inflammation in benign prostate tissue and prostate cancer in the finasteride arm of the Prostate Cancer Prevention Trial [PDF]
, 2016 BACKGROUND: A previous analysis of the placebo arm of the Prostate Cancer Prevention Trial (PCPT) reported 82% overall prevalence of intraprostatic inflammation and identified a link between inflammation and higher-grade prostate cancer and serum PSA ...
Barber, John R +15 more
core +2 more sources
NF-κB signaling in inflammation
Signal Transduction and Targeted Therapy, 2017 The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses.
Ting Liu +3 more
semanticscholar +1 more source
Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u27s disease [PDF]
, 2019 Interest in understanding the roles of white matter (WM) inflammation and damage in the pathophysiology of Alzheimer disease (AD) has been growing significantly in recent years.
Ances, Beau M +14 more
core +2 more sources
Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota
eLife, 2018 As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Eaton et al., 2015) that described how we intended to replicate selected experiments from the paper “Intestinal Inflammation Targets Cancer-Inducing Activity of the ...
Kate Eaton +7 more
semanticscholar +1 more source
A Holistic Approach on Smart Garment for Patients with Juvenile Idiopathic Arthritis [PDF]
10.3390/engproc2023059083;2023, 2023 Juvenile Idiopathic Arthritis (JIA) is a widespread and chronic condition that affects children and adolescents worldwide. The person suffering from JIA is characterized by chronic joint inflammation leading to pain, swelling, stiffness, and limited body movements. Individuals suffering from JIA require ongoing treatment for their lifetime.
arxiv +1 more source
By protecting against cutaneous inflammation, epidermal pigmentation provided an additional advantage for ancestral humans. [PDF]
, 2019 Pigmentation evolved in ancestral humans to protect against toxic, ultraviolet B irradiation, but the question remains: "what is being protected?" Because humans with dark pigmentation display a suite of superior epidermal functions in comparison with ...
Abuabara, Katrina +7 more
core +1 more source