Inflammation and tumor progression: signaling pathways and targeted intervention
Signal Transduction and Targeted Therapy, 2021 Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes.
Huakan Zhao +6 more
semanticscholar +1 more source
Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [PDF]
, 2014 Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and ...
Abe +100 more
core +1 more source
Inflammation in Atherosclerosis
Arteriosclerosis, Thrombosis and Vascular Biology, 2012 Experimental work has elucidated molecular and cellular pathways of inflammation that promote atherosclerosis. Unraveling the roles of cytokines as inflammatory messengers provided a mechanism whereby risk factors for atherosclerosis can alter arterial ...
P. Libby
semanticscholar +1 more source
Imaging infection and inflammation [PDF]
, 2015 No abstract ...
A. W., Glaudemans +3 more
core +1 more source
Pain pathogenesis in rheumatoid arthritis -- what have we learned from animal models [PDF]
PAIN 2018 Sep; 159 Suppl:S98-S109, 2019 Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by joint inflammation and joint pain. Much of RA treatment is focused on suppressing inflammation, with the idea being that if inflammation is controlled other symptoms, such as pain, will disappear. However, pain is the most common complaint of RA patients, is often still present
arxiv +1 more source
Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage [PDF]
, 2015 Background Traumatic brain injury can trigger chronic neuroinflammation, which may predispose to neurodegeneration. Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this ...
Brooks, DJ +5 more
core +1 more source
Dissecting the IL-6 pathway in cardiometabolic disease: A Mendelian randomization study on both IL6 and IL6R [PDF]
, 2022 Aims: Chronic inflammation is a risk factor for cardiovascular disease (CVD). IL-6 signalling perturbation through IL-6 or IL-6R blockade may have potential benefit on cardiovascular risk.
CHARGE Inflammation Working Group
core
JointNET: A Deep Model for Predicting Active Sacroiliitis from Sacroiliac Joint Radiography [PDF]
arXiv, 2023 Purpose: To develop a deep learning model that predicts active inflammation from sacroiliac joint radiographs and to compare the success with radiologists. Materials and Methods: A total of 1,537 (augmented 1752) grade 0 SIJs of 768 patients were retrospectively analyzed.
arxiv
Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection [PDF]
, 2015 Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their impact on the evolution of airway inflammation has not been demonstrated.
Snelgrove, RJ
core +1 more source
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Journal of Experimental Medicine, 2005 Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 cells that are essential for host defense and tumor suppression.
C. Langrish +8 more
semanticscholar +1 more source