Results 31 to 40 of about 4,758,008 (341)

Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster. [PDF]

, 2015
Ageing is an irreversible cellular decline partly driven by failing mitochondrial integrity. Mitochondria accumulate DNA mutations and reduce ATP production necessary for cellular metabolism. This is associated with inflammation.
Begum, R, Calaza, K, Hogg, C, Jeffery, G, Kam, JH, Salt, TE   +5 more
core   +1 more source

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

Cell Death and Disease, 2021
RIPK3 was reported to play an important role in the protection against influenza A virus (IAV) in vivo. Here we show that the requirement of RIPK3 for protection against IAV infection in vivo is only apparent within a limited dose range of IAV challenge.
Teodora Oltean, Emily Van San, Tatyana Divert, Tom Vanden Berghe, Xavier Saelens, Jonathan Maelfait, Nozomi Takahashi, Peter Vandenabeele   +7 more
doaj   +1 more source

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Journal of Experimental Medicine, 2005
Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 cells that are essential for host defense and tumor suppression.
C. Langrish, Yi Chen, W. Blumenschein, J. Mattson, Beth Basham, J. Sedgwick, T. Mcclanahan, R. Kastelein, D. Cua   +8 more
semanticscholar   +1 more source

Effects of lipopolysaccharide-induced inflammation on expression of growth-associated genes by corticospinal neurons [PDF]

, 2006
Background: Inflammation around cell bodies of primary sensory neurons and retinal ganglion cells enhances expression of neuronal growth-associated genes and stimulates axonal regeneration.
Anderson, PN, Hossain-Ibrahim, MK, Lieberman, AR, MacNally, JK, Mason, MRJ, Rezajooi, K   +5 more
core   +2 more sources

CARD14 Signalling Ensures Cell Survival and Cancer Associated Gene Expression in Prostate Cancer Cells

Biomedicines, 2022
Prostate cancer (PCa) is one of the most common cancer types in men and represents an increasing global problem due to the modern Western lifestyle. The signalling adapter protein CARD14 is specifically expressed in epithelial cells, where it has been ...
Domien Vanneste, Jens Staal, Mira Haegman, Yasmine Driege, Marieke Carels, Elien Van Nuffel, Pieter De Bleser, Yvan Saeys, Rudi Beyaert, Inna S. Afonina   +9 more
doaj   +1 more source

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source

Glucocorticoid‐induced microRNA‐511 protects against TNF by down‐regulating TNFR1

EMBO Molecular Medicine, 2015
TNF is a central actor during inflammation and a well‐recognized drug target for inflammatory diseases. We found that the mouse strain SPRET/Ei, known for extreme and dominant resistance against TNF‐induced shock, displays weak expression of TNF receptor
Leen Puimège, Filip Van Hauwermeiren, Sophie Steeland, Sara Van Ryckeghem, Jolien Vandewalle, Sofie Lodens, Lien Dejager, Sofie Vandevyver, Jan Staelens, Steven Timmermans, Roosmarijn E Vandenbroucke, Claude Libert   +11 more
doaj   +1 more source

Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD

Journal of Immunology Research, 2021
We performed a panoramic analysis on both human nonalcoholic steatohepatitis (NASH) microarray data and microarray/RNA-seq data from various mouse models of nonalcoholic fatty liver disease NASH/NAFLD with total 4249 genes examined and made the following
Charles I. V. Drummer, Fatma Saaoud, Yu Sun, Diana Atar, Keman Xu, Yifan Lu, Ying Shao, Candice Johnson, Lu Liu, Huimin Shen, Nirag C. Jhala, Xiaohua Jiang, Hong Wang, Xiaofeng Yang   +13 more
doaj   +1 more source

Inflammation and immune dysfunction in Parkinson disease

Nature reviews. Immunology, 2022
Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral organs as well as the central nervous system and involves a fundamental role of neuroinflammation in its pathophysiology. Neurohistological and neuroimaging studies
M. Tansey, R. Wallings, M. Houser, Mary K. Herrick, C. Keating, V. Joers   +5 more
semanticscholar   +1 more source

Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites [PDF]

, 2017
Inflammation can be protective or pathogenic depending on context and timeframe. Acute inflammation, including the accumulation of CD4 T cells, accompanies protective immune responses to pathogens, but the presence of activated CD4 T cells at sites of ...
Ammit, Barnden, Brinkmann, Brown, Chimen, Cyster, Debes, Faust, Firestein, Fu, Garrod, Gibson, Han, Hochreiter-Hufford, Hugues, Jo, Karuppuchamy, Kitano, Ledgerwood, Liao, Limaye, Lindquist, Mackay, Mackay, Mammoto, Masopust, Matloubian, Matsuura, McInnes, Means, Mempel, Mendoza, Murphy, Nowarski, Olivera, Priceman, Pyne, Sawicka, Skon, Smith, Spangrude, Tarrason, Teijeira, Tsunemi, Veres, Wang, Wang   +46 more
core   +3 more sources