Results 241 to 250 of about 362,551 (290)

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Coupled Plasma Filtration and Adsorption in Eliminating Inflammatory Mediators and Enhancing Sublingual Microcirculation in Severe Acute Pancreatitis. [PDF]

Pancreas
Zhou H, Ma C, Zhong S.
europepmc   +1 more source

Leucine-Rich Alpha-2 Glycoprotein 1 (LRG1) and Proangiogenic Mediators in Sickle Cell Disease [PDF]

Turk J Haematol
Kleebayoon A, Wiwanitkit V.
europepmc   +1 more source

Activation of Myeloid Dendritic Cells by Up-Regulating RAGE/JAK/STAT Pathway Induced by Cigarette Smoke Exposure in Mice With Emphysema. [PDF]

Mediators Inflamm
Gao J, Wang H, Zhou G, Zhou Z, Liang C, Zhong X.   +5 more
europepmc   +1 more source

Podocyte extracellular vesicles and immune mediators as urinary biomarkers in active lupus nephritis. [PDF]

Sci Rep
Alves L, Lemos AP, Martins J, da Costa Fonseca S, Gaudio RC, Lima H, Carvalho C, Ramos A, de Souza Lacerda G, da Fonseca PB, De Felice FG, Cabral-Castro MJ, de Matos JPS, Almeida JR, Burger D, Medeiros T, Silva AA.   +16 more
europepmc   +1 more source

Microbiome-derived metabolites in cancer-associated anemia: An underexplored mechanistic link. [PDF]

World J Gastrointest Pharmacol Ther
Wang Z, Wang F.
europepmc   +1 more source

Leukocyte-type 12/15-lipoxygenase is essential for timely inflammation-resolution and effective tissue regeneration following skeletal muscle injury. [PDF]

Mol Metab
Sharma B, Lu X, Rehman H, Figueiredo VC, Davis C, Van Remmen H, Kuang S, Brooks SV, Maddipati KR, Markworth JF.   +9 more
europepmc   +1 more source