Results 41 to 50 of about 3,890,295 (331)
TL1A: A mediator of gut inflammation [PDF]
Proceedings of the National Academy of Sciences, 2006 In this issue of PNAS, a team of investigators led by Giorgos Bamias and Fabio Cominelli at the University of Virginia Health Science Center (Charlottesville, VA) in collaboration with the laboratory of Giorgos Kollias at the Alexander Fleming Biomedical Sciences Research Center (Athens, Greece) report on the role of TL1A (a TNF superfamily member) in ...
Howard A. Young, Michael G. Tovey
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Sequential release of cytokines, lipid mediators and nitric oxide in experimental colitis
Mediators of Inflammation, 1995 The object of this study was to establish whether different pro- and anti-inflammatory mediators were formed in colonic tissue from experimental colitis depending on the course of the disease.
A. P. M. van Dijk +3 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases
Mediators of Inflammation, 2015 Most chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro- and anti-inflammatory mediators in the liver. These mediators are the driving force of many inflammatory liver disorders, which often
Ting Liu, Yu Zhou, K. Ko, Heping Yang
semanticscholar +1 more source
Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications
Cells, 2020 Parkinson’s disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigra pars compacta.
Marta Pajares +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease
Sultan Qaboos University Medical Journal, 2015 Alzheimer’s disease (AD), a neurodegenerative disorder associated with advanced age, is the most common cause of dementia globally. AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofibrillary tangles and neuro ...
Gholamreza Azizi +5 more
doaj +3 more sources