CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses [PDF]
, 2017 CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target.
A Mantovani +38 more
core +1 more source
NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease. [PDF]
, 2017 Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases, but the cell types and signalling pathways that cause these diseases remain poorly understood ...
Nichols, Randilea D +2 more
core +2 more sources
Long-term risk factors of stoma construction after loose seton placement for Crohn disease–associated perianal fistulas [PDF]
Annals of ColoproctologyPurpose To evaluate long-term outcomes and identify prognostic factors for stoma construction following loose seton placement in patients with Crohn disease (CD)-associated perianal fistulas.
Eiichi Nakao +6 more
doaj +1 more source
Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs : involvement of MAPK and NF-κB pathways [PDF]
, 2014 The terpenoid 17-O-acetylacuminolide (AA) was shown to inhibit the production of several inflammatory mediators. However, the mechanisms by which this compound elicited its anti-inflammatory activity remain to be elucidated.
Achoui, Mouna +5 more
core +1 more source
British Medical Bulletin, 2001 Traditional concepts of the pathogenesis of acute coronary syndromes have changed over the last few years. In particular it has been demonstrated that high-risk lesions are not necessarily angiographically severe. Rather, unstable high risk lesions are the ones composed of large lipid cores and thin fibrous caps.
A, Farzaneh-Far, J, Rudd, P L, Weissberg
openaire +2 more sources
Management of Anal Fistula with Crohn's Disease
Journal of the Anus, Rectum and ColonCrohn's disease (CD) causes gastrointestinal symptoms (i.e., diarrhea and abdominal pain), systemic symptoms (i.e., fatigue, anemia, weight loss, and fever), and perianal fistulas that produce anal pain. Because of the frequent occurrence of diarrhea and
Shota Takano +5 more
doaj +1 more source
How and why systemic inflammation worsens quality of life in patients with advanced cancer [PDF]
, 2017 Introduction: The presence of an innate host systemic inflammatory response has been reported to be a negative prognostic factor in a wide group of solid tumour types in both the operable and advanced setting, both local and distant.
Dolan, Ross D. +4 more
core +1 more source
Oral, nasal and pharyngeal exposure to lipopolysaccharide causes a fetal inflammatory response in sheep. [PDF]
, 2015 BackgroundA fetal inflammatory response (FIR) in sheep can be induced by intraamniotic or selective exposure of the fetal lung or gut to lipopolysaccharide (LPS).
Jobe, Alan H +7 more
core +13 more sources
CCR2+ Macrophages Promote Orthodontic Tooth Movement and Alveolar Bone Remodeling
Frontiers in Immunology, 2022 During mechanical force-induced alveolar bone remodeling, macrophage-mediated local inflammation plays a critical role. Yet, the detailed heterogeneity of macrophages is still unknown.
Hao Xu +21 more
doaj +1 more source
Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer [PDF]
, 2016 In patients with colorectal cancer (CRC), local and systemic inflammatory responses have been extensively reported to associate with cancer survival. However, the specific signalling pathways responsible for inflammatory responses are not clear. The PTEN/
Bennett, Lindsay +7 more
core +3 more sources