Results 121 to 130 of about 156,509 (154)

Chronic Macrolide Therapy in Inflammatory Airways Diseases

Chest, 2010
Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been found to have a large number of antiinflammatory properties in addition to being antimicrobials.
Adam L, Friedlander, Richard K, Albert
openaire   +2 more sources

Nonmicrobial-mediated inflammatory airway diseases—an update

Journal of Physiology and Biochemistry, 2013
In lungs, airways are in constant contact with air, microbes, allergens, and environmental pollutants. The airway epithelium represents the first line of lung defense through different mechanisms, which facilitate clearance of inhaled pathogens and environmental particles while minimizing an inflammatory response.
Polani B, Ramesh Babu, P, Krishnamoorthy
openaire   +2 more sources

Novel therapies for the treatment of inflammatory airway disease

Expert Opinion on Investigational Drugs, 2003
Asthma and chronic obstructive pulmonary disease (COPD) are diseases of the airways with an underlying inflammatory component. The prevalence and healthcare burden of asthma and COPD is still rising and is predicted to continue to rise in the current century.
Maria Belvisi
exaly   +3 more sources

Role of hypoxia in inflammatory upper airway disease

Current Opinion in Allergy & Clinical Immunology, 2008
Hypoxia is a potent stimulus for inflammation and remodeling. Hypoxia develops in chronic sinusitis as shown via tissue oxygen concentrations and colonization with obligate anaerobes. This hypoxia reflects occlusion of the sinus ostia and thereby failure of transepithelial oxygenation, nonvascularized exudates, and the tendency of inflammatory ...
John W, Steinke, Charles R, Woodard, Larry, Borish   +2 more
openaire   +2 more sources

Nitric oxide in upper airways inflammatory diseases

Inflammation Research, 2007
In the human respiratory tract, the main production sites of exhaled nitric oxide (NO) are the nose and paranasal sinuses. In the upper airways, NO has been suggested to be involved at different levels with regulatory, protective, defensive or deleterious effects.
Mauro Maniscalco, Matteo Sofia, Girolamo Pelaia   +2 more
openaire   +3 more sources

The Spectrum of Nonasthmatic Inflammatory Airway Diseases in Adults

Otolaryngologic Clinics of North America, 2010
When the airways are overwhelmed by noxious particles, gases, or microorganisms, inflammatory and immune responses occur that may cause permanent structural changes. One consequence may be an overproduction of mucus and this may overwhelm mucociliary clearance mechanisms and cause a chronic cough phlegm syndrome. The expectorated mucus is usually clear
Sidney S, Braman, Muhanned, Abu-Hijleh
openaire   +2 more sources

Role of inflammation and inflammatory mediators in airways disease

The American Journal of Medicine, 1986
Recent evidence suggests that airway inflammation is linked to hyper-responsiveness of airway smooth muscle. Increases in airway responsiveness after many stimuli are accompanied by increases in inflammatory cells in bronchoalveolar lavage fluid and in the airway epithelium.
openaire   +2 more sources

Update on airways inflammatory diseases

2017
In addition to genetic and environmental factors, airway inflammation is the result of the activation of innate and adaptive immune system, which, in turn, contributes to the onset of harmful structural changes affecting target tissues and leading to several diseases.
Manti, Sara, Leonardi, Salvatore
openaire   +2 more sources

Update on Noninfectious Inflammatory Diseases of the Lower Airway

Veterinary Clinics of North America: Equine Practice, 2015
Inflammatory airway disease and recurrent airway obstruction are 2 nonseptic diseases of the equine respiratory system with a shared cause of exposure to particulate matter. They appear to occupy 2 ends of a spectrum of disease, but are differentiated by history, clinical signs, and response to treatment.
openaire   +2 more sources

Disease models of chronic inflammatory airway disease

Current Opinion in Pulmonary Medicine, 2014
Purpose of reviewThis review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship with these models, induced sputum and inflammatory cell counts will be addressed for phenotype-directed drug development.
Diamant, Zuzana, Clarke, Graham W., Pieterse, Herman, Gispert, Juan   +3 more
openaire   +1 more source