Results 71 to 80 of about 158,758 (202)

Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge

, 2012
Background: Both standard and low-dose allergen provocations are an established tool in asthma research to improve our understanding of the pathophysiological mechanism of allergic asthma.
Rose Markus A, Schulze, Johannes B., Schubert, Ralf, Ulrich Zissler, Sandra Voss, Stefan Zielen, Ralf Schubert, Johannes Schulze, Markus A Rose, Zissler, Ulrich, Zielen Stefan, Rose, Markus A., Zissler Ulrich, Schubert Ralf, Schulze Johannes, Voss, Sandra, Zielen, Stefan, Voss Sandra   +17 more
core   +1 more source

A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes [PDF]

, 2016
Air pollutants have been linked to type 2 diabetes (T2D), hypothesized to act through inflammatory pathways and may induce interleukin-6 gene (IL6) in the airway epithelium. The cytokine interleukin-6 may impact on glucose homeostasis.
Imboden, Medea, Eze, Ikenna C, von Eckardstein, Arnold, Margaret W. Gerbase, Turk, Alexander, Ikenna C. Eze, Christian Schindler, Eze, Ikenna C., Kumar, Ashish, Probst-Hensch, Nicole, Daiana Stolz, Kronenberg, Florian, Medea Imboden, Adam, Martin, Künzli, Nino, Alexander Turk, Stolz, Daiana, Gerbase, Margaret W, Martin Adam, Nino Künzli, Gerbase, Margaret W., Florian Kronenberg, Nicole Probst-Hensch, Schindler, Christian, Arnold von Eckardstein, Ashish Kumar   +25 more
core   +1 more source

Therapeutic potential of elafin in airway inflammatory disease

European Journal of Inflammation
Elafin, which is derived from trappin-2 or pre-elafin by proteolysis, is an endogenous serine protease inhibitor with a low molecular weight. Its inhibitory activity is dependent on anchoring to the extracellular matrix by forming covalent bonds with its
Mingxin He, Yalou Yang, Yanyan Li, Xiangdong Zhou, Li Xu, Ziwei Zhang, Hua Zhang, Qi Li   +7 more
doaj   +1 more source

Suppression of allergic airway inflammation by helminth-induced regulatory T cells

, 2005
Allergic diseases mediated by T helper type (Th) 2 cell immune responses are rising dramatically in most developed countries. Exaggerated Th2 cell reactivity could result, for example, from diminished exposure to Th1 cell–inducing microbial infections ...
Lamb, Jonathan, Mark S. Wilson, Adam Balic, Constance A.M. Finney, Taylor, Matthew D, Finney, Constance A, Matthew D. Taylor, Rick M. Maizels, Maizels, Rick, Jonathan R. Lamb, Wilson, Mark A, Balic, Adam   +11 more
core   +1 more source

Asthma: where is it going?

Brazilian Journal of Medical and Biological Research, 2008
Asthma is characterized by reversible airway obstruction, airway hyperresponsiveness, and airway inflammation. Although our understanding of its pathophysiological mechanisms continues to evolve, the relative contributions of airway hyperresponsiveness ...
D.S. Faffe
doaj  

Investigation of the Anti-Inflammatory Effect of Famotidine in Rats by Evaluation of IL-4, IL-6, TNF-α, and IL-10: Airway Model

Medical Journal of Babylon
Background: Lung inflammatory diseases (such as asthma and chronic obstructive pulmonary disease [COPD])) are widespread inflammatory airway illnesses that are characterized by cough, wheezing, chest tightness, and dyspnea, all of which are symptoms of ...
Wasan Ali Hasan, Manal Abdulkhaliq Ibrahim   +1 more
doaj   +1 more source

FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD)

Frontiers in Cell and Developmental Biology, 2020
The fibroblast growth factor 2 (FGF2) is a potent mitogenic factor belonging to the FGF family. It plays a role in airway remodeling associated with chronic inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease (COPD ...
Yuanyang Tan, Yongkang Qiao, Zhuanggui Chen, Jing Liu, Yanrong Guo, Thai Tran, Kai Sen Tan, De-Yun Wang, Yan Yan, Yan Yan   +9 more
doaj   +1 more source

Inhaled nanomaterials and the respiratory microbiome: clinical, immunological and toxicological perspectives

Particle and Fibre Toxicology, 2018
Our development and usage of engineered nanomaterials has grown exponentially despite concerns about their unfavourable cardiorespiratory consequence, one that parallels ambient ultrafine particle exposure from vehicle emissions.
Tuang Yeow Poh, Nur A’tikah Binte Mohamed Ali, Micheál Mac Aogáin, Mustafa Hussain Kathawala, Magdiel Inggrid Setyawati, Kee Woei Ng, Sanjay Haresh Chotirmall   +6 more
doaj   +1 more source

Large and Small Airway Disease Related to Inflammatory Bowel Disease

, 2017
Although airway disease associated with inflammatory bowel disease is uncommon, its involvement may have severe clinical consequences. This article reviews the breadth of pathologic processes that can be expected in the various sizes of airways, and ...
Kenrry Chiu, Joanne Lynne Wright
core   +1 more source

Novel Method to Process Cystic Fibrosis Sputum for Determination of Oxidative State [PDF]

, 2010
Background: Induced sputum is the most commonly used method to analyze airway inflammation in cystic fibrosis (CF) patients ex vivo. Due to the complex matrix of the sample material, precise and reliable analysis of sputum constituents depends critically
Jonas, F., Hector, A., Kappler, M., Feilcke, M., Griese, M., Hartl, D.   +5 more
core   +1 more source