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Colonic Tissue Expression of MAdCAM‐1 Is Not Predictive of Vedolizumab Responsiveness in Inflammatory Bowel Disease [PDF]

Clinical and Translational Science
We assessed the predictive value of MAdCAM‐1 expression on response to vedolizumab in patients with inflammatory bowel disease. This was a retrospective, single‐center, cohort study including 109 patients with pretreatment inflammation who completed at ...
Nikhil Reddy, Jeremy A. Klein, Nikita Thomas, Dejan Micic, Zifeng Deng, David T. Rubin, Russell D. Cohen, Sushila Dalal, Britt Christensen, Haider I. Haider, Vesta Valuckaite, Katherine R. Meckel, Marc Bissonnette, Christopher R. Weber, Joel Pekow   +14 more
doaj   +2 more sources

Novel Utility of Leucine-Rich Alpha-2-Glycoprotein as a Biomarker in Ulcerative Colitis: A Predictor of Endoscopic Remission Independent of Symptoms

Inflammatory Intestinal Diseases, 2023
Introduction: Leucine-rich alpha-2-glycoprotein (LRG) is a potential biomarker for disease activity and reflects mucosal healing in patients with ulcerative colitis (UC).
Tomoyuki Hayashi, Kazuya Kitamura, Masaaki Usami, Masaki Miyazawa, Masaki Nishitani, Akihiro Dejima, Makoto Yamamoto, Shotaro Kawase, Masaya Funaki, Noriaki Orita, Hidetoshi Nakagawa, Koki Morita, Noriho Iida, Akihiro Seki, Kouki Nio, Hidenori Kido, Hideo Takayama, Yuta Takeuchi, Shinya Yamada, Hajime Takatori, Mari Shimada, Hiroto Saito, Daisuke Yamamoto, Tadashi Toyama, Taro Yamashita   +24 more
doaj   +1 more source

Endoplasmic Reticulum Stress in Colonic Mucosa of Ulcerative Colitis Patients Is Mediated by PERK and IRE1 Pathway Activation

Mediators of Inflammation, 2022
Ulcerative colitis (UC) is characterized by a chronic overproduction of proinflammatory cytokines. During an acute phase, the endoplasmic reticulum (ER) is overloaded and the protein folding process is impaired, a condition named ER stress.
Bruno Lima Rodrigues, Isabella Dotti, Lívia Bitencourt Pascoal, Joseane Morari, Miriam Esteller, Andressa Coope, Maria de Lourdes Setsuko Ayrizono, Azucena Salas, Raquel Franco Leal   +8 more
doaj   +1 more source

Impact of the body mass index on the retention of the anorectal mucosa after double-stapled ileal pouch-anal anastomosis for ulcerative colitis

BMC Gastroenterology, 2023
Background Double-stapled ileal pouch-anal anastomosis (DS-IPAA) is easy to construct and has a good functional outcome in patients with ulcerative colitis (UC). However, retention of the anorectal mucosa may lead to a subsequent risk of inflammation and
Hideaki Kimura, Kenichiro Toritani, Reiko Kunisaki, Kenji Tatsumi, Kazutaka Koganei, Akira Sugita, Itaru Endo   +6 more
doaj   +1 more source

Clinicopathological and prognostic evaluations of anorectal cancer after fecal diversion for patients with Crohn’s disease

BMC Gastroenterology, 2021
Purpose Colorectum diversion with a proximal stoma is often the preferred surgical approach in patients with Crohn's disease-related anorectal lesions or refractory colitis.
Hirosuke Kuroki, Akira Sugita, Kazutaka Koganei, Kenji Tatsumi, Ryo Futatsuki, Eiichi Nakao, Nao Obara, Katsuhiko Arai   +7 more
doaj   +1 more source

Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis

BMC Surgery, 2023
Purpose The aim of this study was to compare the clinical characteristics of ulcerative colitis (UC) patients who underwent surgery for cancer/dysplasia with those who underwent surgery for refractory disease and to discuss the preoperative preparation ...
Ryuichi Kuwahara, Hiroki Ikeuchi, Kurando Kusunoki, Tomohiro Minagawa, Yuki Horio, Kei Kimura, Kozo Kataoka, Naohito Beppu, Masataka Ikeda, Motoi Uchino   +9 more
doaj   +1 more source

Vedolizumab for perianal fistulizing Crohn’s disease: systematic review and meta-analysis [PDF]

Intestinal Research, 2022
Background/Aims Perianal fistulas are a debilitating manifestation of Crohn’s disease (CD). Despite the advent of anti-tumor necrosis factor (anti-TNF) therapy, the medical management of fistulizing CD continues to be challenged by unmet needs.
Fares Ayoub, Matthew Odenwald, Dejan Micic, Sushila R. Dalal, Joel Pekow, Russell D. Cohen, David T. Rubin, Atsushi Sakuraba   +7 more
doaj   +1 more source

Cap polyposis treated with laparoscopic-assisted total proctocolectomy and ileal J-pouch anal anastomosis: a case report

Surgical Case Reports, 2021
Background Cap polyposis (CP) is extremely rare in Japan, and there is no established cure. We report a case in which CP was improved by surgical treatment.
Tomohiro Minagawa, Hiroki Ikeuchi, Kurando Kusunoki, Ryuichi Kuwahara, Yuki Horio, Takako Kihara, Seiichi Hirota, Motoi Uchino   +7 more
doaj   +1 more source

A decade of inflammatory bowel disease: a single center experience in Egypt

The Egyptian Journal of Internal Medicine, 2022
Background Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract and includes ulcerative colitis and Crohn’s disease. Inflammatory bowel disease has always seemed to be rare in the Middle East and Northern Africa. In
Mostafa Abd Alfattah Shamkh, Mohamed Amin Sakr, Waleed Hamed Abd Alaty, Shimaa Youssef Kamel, Mohamed Mahmoud Eltabbakh, Ahmed Fouad Sherief, Heba Rashad, Safaa Askar   +7 more
doaj   +1 more source

Clinical Results of One-stage Restorative Proctocolectomy with J-pouch Anal Anastomosis in 300 Ulcerative Colitis Patients

Journal of the Anus, Rectum and Colon, 2020
Objectives: Restorative proctocolectomy and ileal pouch anal anastomosis (IPAA), with diverting ileostomy, are established ulcerative colitis (UC) treatments.
Ryuichi Kuwahara, Hiroki Ikeuchi, Toshihiro Bando, Hirohumi Sasaki, Yoshiko Goto, Yuki Horio, Tomohiro Minagawa, Motoi Uchino   +7 more
doaj   +1 more source