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Oral Diseases (2011) 18, 1–15This review focuses on the prominent etiological and pathogenetic aspects of inflammatory bowel disease (IBD), with particular attention being paid to the mucosal immune response to commensal micro‐organisms in health and disease. Pathogenetic implications for target therapy will also be discussed. The clinical presentation,
E. Szigethy, L. McLafferty, A. Goyal
semanticscholar +7 more sources
Inflammatory bowel disease [PDF]
Inflammatory bowel diseases (IBDs) encompass ulcerative colitis, Crohn's disease, and indeterminate colitis, all of which are characterized by remission and exacerbation of gastrointestinal symptoms, and a variety of extraintestinal manifestations including those affecting the oral cavity.
Clara, Abraham, Judy H, Cho
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Introduction: Leucine-rich alpha-2-glycoprotein (LRG) is a potential biomarker for disease activity and reflects mucosal healing in patients with ulcerative colitis (UC).
Tomoyuki Hayashi+24 more
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Inflammatory bowel disease [PDF]
Scandinavian researchers have contributed to the present understanding of inflammatory bowel disease (IBD). Important epidemiological data and family risk factors have been reported from all the Nordic countries, original twin studies mainly from Denmark and Sweden, and relationships to cancer and surgery mostly from Sweden.
Vatn, Morten H, Sandvik, Arne Kristian
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Pathophysiology of Inflammatory Bowel Disease: Innate Immune System
Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause.
Angela Sáez+4 more
semanticscholar +1 more source
Ulcerative colitis (UC) is characterized by a chronic overproduction of proinflammatory cytokines. During an acute phase, the endoplasmic reticulum (ER) is overloaded and the protein folding process is impaired, a condition named ER stress.
Bruno Lima Rodrigues+8 more
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Background Double-stapled ileal pouch-anal anastomosis (DS-IPAA) is easy to construct and has a good functional outcome in patients with ulcerative colitis (UC). However, retention of the anorectal mucosa may lead to a subsequent risk of inflammation and
Hideaki Kimura+6 more
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Purpose Colorectum diversion with a proximal stoma is often the preferred surgical approach in patients with Crohn's disease-related anorectal lesions or refractory colitis.
Hirosuke Kuroki+7 more
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BACKGROUND The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) has proposed treatment-targets in 2015 for adult IBD patients.
D. Turner+19 more
semanticscholar +1 more source
Vedolizumab for perianal fistulizing Crohn’s disease: systematic review and meta-analysis [PDF]
Background/Aims Perianal fistulas are a debilitating manifestation of Crohn’s disease (CD). Despite the advent of anti-tumor necrosis factor (anti-TNF) therapy, the medical management of fistulizing CD continues to be challenged by unmet needs.
Fares Ayoub+7 more
doaj +1 more source