Results 21 to 30 of about 368,931 (281)

Rectal-sparing type of ulcerative colitis predicts lack of response to pharmacotherapies

BMC Surgery, 2017
Background Ulcerative colitis (UC) is known as an immune disorder of the colon that generally involves the rectum, but an atypical distribution of inflamed mucosa has previously been noted in certain subtypes of UC, such as the rectal-sparing type (RST).
Yuki Horio, Motoi Uchino, Toshihiro Bando, Teruhiro Chohno, Hirofumi Sasaki, Akihiro Hirata, Yoshio Takesue, Hiroki Ikeuchi   +7 more
doaj   +1 more source

Associations between Pouchitis and Fecal Calprotectin after Restorative Proctocolectomy in Patients with Ulcerative Colitis

Inflammatory Intestinal Diseases, 2023
Introduction: Recently, fecal calprotectin has been identified and used as an assessment tool for the confirmation of disease activity in ulcerative colitis.
Motoi Uchino, Yuki Horio, Ryuichi Kuwahara, Kurando Kusunoki, Kentaro Nagano, Hiroki Ikeuchi   +5 more
doaj   +1 more source

The Use of Oral Herbal Medicine (Hange-Shashin-To) in Patients with Pouchitis: A Pilot Study

Journal of the Anus, Rectum and Colon, 2018
Objectives: Hange-Shashin-To (HST), which is a combination of seven herbs, has previously been used in the treatment of inflammatory or ulcerative gut disease.
Hiroki Matsuoka, Motoi Uchino, Yuki Horio, Hirofumi Sasaki, Teruhiro Chohno, Akihiro Hirata, Toshihiro Bando, Takashi Ito, Toshimasa Yamaguchi, Hiroki Ikeuchi   +9 more
doaj   +1 more source

Faecal calprotectin level for assessing endoscopic activity and predicting future clinical course in patients with moderately active ulcerative colitis undergoing granulomonocytapheresis: a prospective cohort study

BMC Gastroenterology, 2018
Background Calprotectin is a stable neutrophil protein, which can be measured in faecal samples. The faecal level of calprotectin increases during disease activity in ulcerative colitis (UC).
Takahiro Shimoyama, Takayuki Yamamoto, Satoru Umegae, Koichi Matsumoto   +3 more
doaj   +1 more source

Long-term risk factors of stoma construction after loose seton placement for Crohn disease–associated perianal fistulas [PDF]

Annals of Coloproctology
Purpose To evaluate long-term outcomes and identify prognostic factors for stoma construction following loose seton placement in patients with Crohn disease (CD)-associated perianal fistulas.
Eiichi Nakao, Kenji Tatsumi, Nao Obara, Koki Goto, Hirosuke Kuroki, Akira Sugita, Kazutaka Koganei   +6 more
doaj   +1 more source

Have advances in medical therapy for ulcerative colitis impacted surgical treatment?

Annals of Gastroenterological Surgery, 2023
Aim The purpose of this study was to examine how the clinical characteristics, indications for surgery, and postoperative course of ulcerative colitis (UC) surgical patients changed before and after the introduction of biological agents. Methods Patients
Ryuichi Kuwahara, Hiroki Ikeuchi, Yuki Horio, Tomohiro Minagawa, Kurando Kusunoki, Motoi Uchino   +5 more
doaj   +1 more source

Review of the safety with biologics in inflammatory bowel disease

Journal of IMIDs, 2022
Biologics have completely changed the treatment (and life) of patients with inflammatory bowel disease (IBD). After the first ones, anti-tumor necrosis factor (TNF) biologics, two new biologics, with other therapeutic targets, are now in routine use in ...
Andrea Pascual, Raquel Vicente, Eva Sierra, Santiago García-López   +3 more
doaj   +1 more source

GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2

Clinical and Translational Medicine, 2022
G protein‐coupled receptor 65 (GPR65), a susceptibility gene for inflammatory bowel diseases (IBD), has been identified to promote Th17 cell pathogenicity and induce T cell apoptosis.
Ritian Lin, Wei Wu, Huimin Chen, Han Gao, Xiaohan Wu, Gengfeng Li, Qiong He, Huiying Lu, Mingming Sun, Zhanju Liu   +9 more
doaj   +1 more source

Management of Anal Fistula with Crohn's Disease

Journal of the Anus, Rectum and Colon
Crohn's disease (CD) causes gastrointestinal symptoms (i.e., diarrhea and abdominal pain), systemic symptoms (i.e., fatigue, anemia, weight loss, and fever), and perianal fistulas that produce anal pain. Because of the frequent occurrence of diarrhea and
Shota Takano, Yasushi Nakamura, Kohei Tamaoka, Takafumi Yoshimoto, Yasue Irei, Yoriyuki Tsuji   +5 more
doaj   +1 more source

Evaluation of changes in intestinal microbiota in Crohn’s disease patients after anti-TNF alpha treatment

Scientific Reports, 2021
Intestinal dysbiosis is key in the onset and development of Crohn’s disease (CD). We evaluated the microbiota changes in CD patients before and after a six-month anti-TNF treatment, comparing these changes with the microbiota of healthy subjects.
Laura Sanchis-Artero, Juan Francisco Martínez-Blanch, Sergio Manresa-Vera, Ernesto Cortés-Castell, Marina Valls-Gandia, Marisa Iborra, Jose Maria Paredes-Arquiola, Maia Boscá-Watts, Jose Maria Huguet, Rafael Gil-Borrás, Josefa Rodríguez-Morales, Xavier Cortés-Rizo   +11 more
doaj   +1 more source