Results 41 to 50 of about 1,049,512 (355)

GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2

Clinical and Translational Medicine, 2022
G protein‐coupled receptor 65 (GPR65), a susceptibility gene for inflammatory bowel diseases (IBD), has been identified to promote Th17 cell pathogenicity and induce T cell apoptosis.
Ritian Lin, Wei Wu, Huimin Chen, Han Gao, Xiaohan Wu, Gengfeng Li, Qiong He, Huiying Lu, Mingming Sun, Zhanju Liu   +9 more
doaj   +1 more source

Pouchitis in inflammatory bowel disease: a review of diagnosis, prognosis, and treatment [PDF]

Intestinal Research, 2021
Patients with inflammatory bowel disease (IBD) occasionally need a restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) because of medically refractory colitis or dysplasia/cancer.
Shintaro Akiyama, Victoria Rai, David T. Rubin   +2 more
doaj   +1 more source

Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2005
The discovery of a series of genetic and serological markers associated with disease susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an integrated classification system involving clinical, serological and genetic ...
M. Silverberg, J. Satsangi, T. Ahmad, I. Arnott, C. Bernstein, S. Brant, R. Caprilli, J. Colombel, C. Gasche, K. Geboes, D. Jewell, Amir S Karban, E. Loftus, A. Peña, R. Riddell, Frcpc FRCPath, D. Sachar, S. Schreiber, A. Steinhart, S. Targan, S. Vermeire, B. Warren   +21 more
semanticscholar   +1 more source

Cytokines in inflammatory bowel disease [PDF]

Mediators of Inflammation, 1997
Over the past decade, much has been learned regarding the role of various cytokines in the pathogenesis of inflammatory bowel disease. Several cytokine ‘knockout’ models in mice have been shown to develop colitis, while alterations in the production of various cytokines has been documented in human Crohn′s disease and ulcerative colitis.
Beck, P. L., Wallace, J. L.
openaire   +5 more sources

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

Genome Biology, 2012
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes and the immune system. However, the precise dysfunctions of microbial metabolism in the gastrointestinal microbiome during IBD ...
X. Morgan, Timothy L. Tickle, H. Sokol, D. Gevers, K. Devaney, D. Ward, Joshua A Reyes, Samir A. Shah, N. LeLeiko, S. Snapper, A. Bousvaros, J. Korzenik, B. Sands, R. Xavier, C. Huttenhower   +14 more
semanticscholar   +1 more source

Enterogenous Microbiotic Markers in the Differential Diagnosis of Crohn’s Disease and Intestinal Tuberculosis

Frontiers in Immunology, 2022
Crohn’s disease (CD) is a chronic intestinal disorder characterized by refractory gastrointestinal ulcerations. Intestinal tuberculosis (ITB) is one common intestinal disease in east Asia.
Mingshan Jiang, Mingshan Jiang, Mingshan Jiang, Zhen Zeng, Zhen Zeng, Zhen Zeng, Kexin Chen, Kexin Chen, Kexin Chen, Yuan Dang, Yuan Dang, Yuan Dang, Lili Li, Lili Li, Lili Li, Chunxiang Ma, Chunxiang Ma, Chunxiang Ma, Rui Cheng, Rui Cheng, Rui Cheng, Kehan Hu, Kehan Hu, Kehan Hu, Xi Li, Xi Li, Xi Li, Hu Zhang, Hu Zhang, Hu Zhang   +29 more
doaj   +1 more source

Management of Anal Fistula with Crohn's Disease

Journal of the Anus, Rectum and Colon
Crohn's disease (CD) causes gastrointestinal symptoms (i.e., diarrhea and abdominal pain), systemic symptoms (i.e., fatigue, anemia, weight loss, and fever), and perianal fistulas that produce anal pain. Because of the frequent occurrence of diarrhea and
Shota Takano, Yasushi Nakamura, Kohei Tamaoka, Takafumi Yoshimoto, Yasue Irei, Yoriyuki Tsuji   +5 more
doaj   +1 more source

Rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features arising in a patient with ulcerative colitis: a case report

World Journal of Surgical Oncology, 2022
Background Colorectal carcinoma with enteroblastic differentiation is a rare subtype of colorectal carcinomas expressing at least one characteristic immunohistochemical marker among α-fetoprotein, glypican-3, and spalt-like transcription factor 4. On the
Takako Kihara, Ryuichi Kuwahara, Kurando Kusunoki, Tomohiro Minagawa, Yuki Horio, Motoi Uchino, Hiroki Ikeuchi, Seiichi Hirota   +7 more
doaj   +1 more source

History of Inflammatory Bowel Diseases [PDF]

Journal of Clinical Medicine, 2019
Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal mucosa and unknown etiology. In this review, we identified three main eras in the IBD history. Between the 19th and the 20th century, the primary task had been the definition of the diagnostic criteria in order to differentiate the new entity from intestinal ...
Giovanni Clemente Actis, Rinaldo Pellicano, Sharmila Fagoonee, Davide Giuseppe Ribaldone   +3 more
openaire   +4 more sources

Prolonged time to treatment of biologics in inflammatory bowel disease: disparities from a retrospective study in a tertiary referral centre in the UK

BMC Gastroenterology
Background Several disparities in healthcare utilisation and delivery are reported in inflammatory bowel disease (IBD). We examined disparities for delays in biologic administration.
Charlotte Wong, Paul Bassett, Nikolaos Kamperidis, Ravi Misra, Lisa Younge, Lovesh Dyall, Katie Yeung, Christy Rejee, Naila Arebi   +8 more
doaj   +1 more source