Results 181 to 190 of about 430,745 (290)

Is the emergence of inflammatory bowel disease a prime example of “the third epidemiological transition”? [PDF]

, 2018
Saurabh Kedia, Vineet Ahuja
openalex   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Gaps in knowledge and future directions for the use of faecal microbiota transplant in the treatment of inflammatory bowel disease [PDF]

, 2019
Mehmet Yalchin, Jonathan Segal, Benjamin H. Mullish, Mohammed Nabil Quraishi, Tariq Iqbal, Julian R. Marchesi, Ailsa Hart   +6 more
openalex   +1 more source

Effects of Combined Prebiotic, Probiotic, IgG and Amino Acid Supplementation on the Gut Microbiome Of Patients With Inflammatory Bowel Disease

, 2022
Massimo Marzorati, Sarah S. Bubeck, Thomas Bayne, Kiran Krishnan, Morgan Giusto   +4 more
openalex   +1 more source

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

Challenges in screening for latent tuberculosis in inflammatory bowel disease prior to biologic treatment: a UK cohort study [PDF]

, 2018
Aye Aye Thi, Aula Abbara, Sonia Bouri, Simon M. Collin, Paul Wolfson, Leah A. Owen, Kevin G. Buell, Laurence John, Ailsa Hart   +8 more
openalex   +1 more source

Roles of Deubiquitinases OTUD3 and OTUD5 in Inflammatory Bowel Diseases. [PDF]

Int J Mol Sci
Watanabe T, Kudo M.
europepmc   +1 more source

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Chemerin as a biomarker of inflammatory bowel diseases: a meta-analysis. [PDF]

BMC Gastroenterol
Tian Z, Xiang Q, Long M, Liao J, Wang F, Li X.   +5 more
europepmc   +1 more source

Oral Celastrol Micelles Forming High‐Density Lipoprotein Corona Targeting Hepatocytes for MASLD Treatment

Advanced Science, EarlyView.
Upon oral administration, OPDEA‐PCL/CEL micelles passed through the stomach acid intact, then quickly penetrated the intestinal mucus and transported into circulation, where they captured HDL to form a protein corona and target hepatocyte SR‐B1 receptors, inducing endocytosis.
Chang Xu, Haoru Zhu, Kai Wang, Haitao Hu, Xuyong Wei, Dongdong Xu, Jing Zhang, Yanpeng Liu, Jun Chen, Youqing Shen, Nasha Qiu, Xiao Xu   +11 more
wiley   +1 more source